Protein Domain : IPR015631

Type:  Family Name:  Signalling lymphocyte activation molecule family receptors
Description:  Members of the signalling lymphocyte activation molecule (SLAM) family of receptors are expressed in multiple cells of the immune system, including natural killer cells, T cells, and B cells []. SLAM receptors interact with SH2 domain-containing, cytosolic adaptor proteins such as SAP, EAT-2, and SH2D1A, and mediate tyrosine phosphorylation events that contribute to immune cell activation. The finding that mutations in SAP are associated with an X-linked lymphoproliferative disorder [] suggests that signalling through SLAM receptors can influence the development and effector functions of immune cells. Short Name:  SLAM_fam_rcpts
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2 Child Features

DB identifier Type Name
IPR024304 Family Natural killer cell receptor 2B4
IPR015632 Family T-cell surface antigen CD2

1 Contains

DB identifier Type Name
IPR007110 Domain Immunoglobulin-like domain

1 Cross References

Identifier
PTHR12080

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004872 IPR015631
GO:0005515 IPR015631
GO:0016021 IPR015631

3 Ontology Annotations

GO Term Gene Name
GO:0004872 IPR015631
GO:0005515 IPR015631
GO:0016021 IPR015631

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12787752
            11034354