Type: | Family | Name: | Recoverin family |
Description: | Recoverin is a Ca(2+) -binding protein that controls phosphorylation of the visual receptor rhodopsin by inhibiting rhodopsin kinase (GRK-1) in photoreceptor cells [, ]. It serves as a cancer-retina antigen that is expressed in retina and tumour cells and evokes antibodies and/or T cells in patients with cancer [, ]. A number of other proteins including visinin, hippocalcin, neurocalcin, S-modulin, visinin-like protein, frequenin, guanylyl cyclase-activating proteins GCAP-1 and GCAP-2 [] belong to this family. All of the family members are generally small N-myristoylated proteins containing four EF-hand calcium-binding consensus motifs. | Short Name: | Recoverin |