Protein Domain : IPR018517

Type:  Conserved_site Name:  tRNA-dihydrouridine synthase, conserved site
Description:  Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of tRNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. Dus 1 () from Saccharomyces cerevisiae(Baker's yeast) acts on pre-tRNA-Phe, while Dus 2 () acts on pre-tRNA-Tyr and pre-tRNA-Leu. Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD []. Some family members may be targeted to the mitochondria and even have a role in mitochondria []. The signature pattern used in this entry contains a conserved cysteine which could be one of the active site residues. Short Name:  tRNA_hU_synthase_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS01136

4 Found Ins

DB identifier Type Name
IPR013785 Domain Aldolase-type TIM barrel
IPR001269 Family tRNA-dihydrouridine synthase
IPR004652 Family tRNA-dihydrouridine synthase, TIM-barrel, NifR3
IPR004653 Family tRNA dihydrouridine synthase A

4 GO Annotations

GO Term Gene Name
GO:0017150 IPR018517
GO:0050660 IPR018517
GO:0008033 IPR018517
GO:0055114 IPR018517

4 Ontology Annotations

GO Term Gene Name
GO:0017150 IPR018517
GO:0050660 IPR018517
GO:0008033 IPR018517
GO:0055114 IPR018517

0 Parent Features

0 Proteins

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12003496