Protein Domain : IPR004653

Type:  Family Name:  tRNA dihydrouridine synthase A
Description:  This family represents one branch of (Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family) although NifR3 itself, a protein of unknown function associated with nitrogen regulation in Rhodobacter capsulatus, is not a member of this branch. Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA []. They show a distant relationship to alpha/beta (TIM) barrel enzymes suchas dihydroorotate dehydrogenase and glycolate oxidase. Short Name:  DusA
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0 Child Features

1 Contains

DB identifier Type Name
IPR018517 Conserved_site tRNA-dihydrouridine synthase, conserved site

1 Cross References

Identifier
TIGR00742

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0016491 IPR004653
GO:0017150 IPR004653
GO:0050660 IPR004653
GO:0008033 IPR004653
GO:0055114 IPR004653

5 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR004653
GO:0017150 IPR004653
GO:0050660 IPR004653
GO:0008033 IPR004653
GO:0055114 IPR004653

1 Parent Features

DB identifier Type Name
IPR001269 Family tRNA-dihydrouridine synthase

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1BdTR11A1040577m.p PAC:35688520 Brachypodium distachyon BdTR11a 331  
Brdisv1BdTR11A1041289m.p PAC:35690246 Brachypodium distachyon BdTR11a 410  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12003496