Protein Domain : IPR006029

Type:  Domain Name:  Neurotransmitter-gated ion-channel transmembrane domain
Description:  Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [, ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily:Nicotinic acetylcholine receptor (AchR), an excitatory cation channel in vertebrates and invertebrates; in vertebrate motor endplates it is composed of alpha, beta, gamma and delta/epsilon subunits; in neurons it is composed of alpha and non-alpha (or beta) subunits [].Glycine receptor, an inhibitory chloride ion channel composed of alpha and beta subunits [].Gamma-aminobutyric acid (GABA) receptor, an inhibitory chloride ion channel; at least four types of subunits (alpha, beta, gamma and delta) are known [].Serotonin 5HT3 receptor, of which there are seven major types (5HT3-5HT7) [].Glutamate receptor, an excitatory cation channel of which at least three types have been described (kainate, N-methyl-D-aspartate (NMDA) and quisqualate) [].These receptors possess a pentameric structure (made up of varying subunits), surrounding a central pore. All known sequences of subunits from neurotransmitter-gated ion-channels are structurally related. They are composed of a large extracellular glycosylated N-terminal ligand-binding domain, followed by three hydrophobic transmembrane regions which form the ionic channel, followed by an intracellular region of variable length. A fourth hydrophobic region is found at the C-terminal of the sequence [, ].This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels. Short Name:  Neurotrans-gated_channel_TM
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF02932
SSF90112

30 Found Ins

DB identifier Type Name
IPR006201 Family Neurotransmitter-gated ion-channel
IPR002394 Family Nicotinic acetylcholine receptor
IPR002289 Family Gamma-aminobutyric-acid A receptor, beta subunit
IPR006028 Family Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR005437 Family Gamma-aminobutyric-acid A receptor, gamma subunit
IPR005438 Family Gamma-aminobutyric-acid A receptor, gamma 1 subunit
IPR005439 Family Gamma-aminobutyric-acid A receptor, gamma 2 subunit
IPR005440 Family Gamma-aminobutyric-acid A receptor, gamma 3 subunit
IPR005435 Family Gamma-aminobutyric-acid A receptor, alpha 5 subunit
IPR001390 Family Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005436 Family Gamma-aminobutyric-acid A receptor, alpha 6 subunit
IPR005433 Family Gamma-aminobutyric-acid A receptor, alpha 3 subunit
IPR005434 Family Gamma-aminobutyric-acid A receptor, alpha 4 subunit
IPR005431 Family Gamma-aminobutyric-acid A receptor, alpha 1 subunit
IPR005432 Family Gamma-aminobutyric-acid A receptor, alpha 2 subunit
IPR015680 Family Glutamate-Gated Chloride Channel
IPR008059 Family Gamma-aminobutyric-acid A receptor, Rho2
IPR008057 Family Gamma-aminobutyric-acid A receptor, Rho
IPR008058 Family Gamma-aminobutyric-acid A receptor, Rho1
IPR008060 Family Glycine receptor beta
IPR008099 Family Gamma-aminobutyric-acid A receptor epsilon subunit
IPR008098 Family Gamma-aminobutyric-acid A receptor delta subunit
IPR008129 Family Glycine receptor alpha2
IPR008128 Family Glycine receptor alpha1
IPR008130 Family Glycine receptor alpha3
IPR008134 Family 5-hydroxytryptamine 3 receptor, B subunit
IPR008132 Family 5-hydroxytryptamine 3 receptor
IPR008133 Family 5-hydroxytryptamine 3 receptor, A subunit
IPR008101 Family Gamma-aminobutyric-acid A receptor theta subunit
IPR008100 Family Gamma-aminobutyric-acid A receptor pi subunit

2 GO Annotations

GO Term Gene Name
GO:0006811 IPR006029
GO:0016020 IPR006029

2 Ontology Annotations

GO Term Gene Name
GO:0006811 IPR006029
GO:0016020 IPR006029

0 Parent Features

613 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
29794.m003495 B9RS95 PAC:16808853 Ricinus communis 437  
Cucsa.052700.1 A0A0A0KHN9 PAC:16954268 Cucumis sativus 285  
Cucsa.285880.1 PAC:16974914 Cucumis sativus 364  
orange1.1g041492m A0A067DZR9 PAC:18125516 Citrus sinensis 73  
orange1.1g023208m A0A067G3Z9 PAC:18097215 Citrus sinensis 285  
orange1.1g025283m A0A067EKG4 PAC:18130453 Citrus sinensis 255  
orange1.1g044754m A0A067F4N8 PAC:18104160 Citrus sinensis 172  
orange1.1g029336m A0A067F3I2 PAC:18123914 Citrus sinensis 195  
orange1.1g024312m A0A067EV35 PAC:18123912 Citrus sinensis 269  
orange1.1g024319m A0A067ERF2 PAC:18123913 Citrus sinensis 269  
AT4G28050.1 Q9SUD4 PAC:19644832 Arabidopsis thaliana 263  
AT3G24770.1 Q84W98 PAC:19665121 Arabidopsis thaliana 99  
Thhalv10025997m V4MGN4 PAC:20195602 Eutrema salsugineum 264  
Thhalv10023642m V4KD62 PAC:20200831 Eutrema salsugineum 264  
Ciclev10028995m V4UEZ2 PAC:20814038 Citrus clementina 285  
Ciclev10010303m V4WJ16 PAC:20792895 Citrus clementina 279  
Ciclev10009193m V4UF67 PAC:20794286 Citrus clementina 269  
Lus10029562 PAC:23152041 Linum usitatissimum 270  
Lus10015494 PAC:23173655 Linum usitatissimum 270  
Potri.001G023700.1 B9GM38 PAC:27048028 Populus trichocarpa 146  
Potri.003G022900.1 A0A2K2B0E6 PAC:26999403 Populus trichocarpa 775  
Potri.013G069900.1 PAC:26994422 Populus trichocarpa 533  
Potri.019G097900.1 A0A2K1WS42 PAC:27025219 Populus trichocarpa 116  
Gorai.001G011200.2 A0A0D2N346 PAC:26821303 Gossypium raimondii 266  
Gorai.001G011200.1 A0A0D2PIY8 PAC:26821304 Gossypium raimondii 266  
Gorai.004G104300.1 A0A0D2P9R8 PAC:26777550 Gossypium raimondii 272  
Gorai.004G209600.2 A0A0D2R1A1 PAC:26773033 Gossypium raimondii 265  
Gorai.004G209600.5 A0A0D2S393 PAC:26773034 Gossypium raimondii 253  
Gorai.004G273300.1 A0A0D2N4F0 PAC:26774914 Gossypium raimondii 265  
Gorai.012G130900.1 A0A0D2V4T4 PAC:26828362 Gossypium raimondii 54  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1721053
            1846404
            10026168
            18446614
            15383648
            18760291
            15165736