Protein Domain : IPR000675

Type:  Domain Name:  Cutinase
Description:  Aerial plant organs are protected by a cuticle composed of an insoluble polymeric structural compound, cutin, which is a polyester composed of hydroxy and hydroxyepoxy fatty acids. Plant pathogenicfungi produce extracellular degradative enzymes [] that play an important role in pathogenesis.They include cutinase, which hydrolyses cutin, facilitating fungus penetration through the cuticle. Inhibition of the enzyme can prevent fungal infection through intact cuticles. Cutin monomers released from the cuticleby small amounts of cutinase on fungal spore surfaces can greatly increase the amount of cutinase secreted by the spore, the mechanism for which process is as yet unknown [].Cutinase is a serine esterase containing the classical Ser, His, Asp triad of serine hydrolases. The protein belongs to the alpha-beta class, with a central beta-sheet of 5 parallel strands covered by 5helices on either side of the sheet. The active site cleft is partly covered by 2 thin bridges formed by amino acid side chains, by contrast with the hydrophobic lid possessed by other lipases []. The protein also contains 2 disulphide bridges, which are essential for activity, their cleavage resulting in complete loss of enzymatic activity. Two cutinase-like proteins (MtCY39.35 and MtCY339.08c) have been found in the genome of the bacteria Mycobacterium tuberculosis. Short Name:  Cutinase
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0 Child Features

0 Contains

1 Cross References

Identifier
PF01083

1 Found In

DB identifier Type Name
IPR011150 Family Cutinase, monofunctional

2 GO Annotations

GO Term Gene Name
GO:0016787 IPR000675
GO:0008152 IPR000675

2 Ontology Annotations

GO Term Gene Name
GO:0016787 IPR000675
GO:0008152 IPR000675

1 Parent Features

DB identifier Type Name
IPR029058 Domain Alpha/Beta hydrolase fold

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Caamp.0058s0134.1.p PAC:39078765 Caulanthus amplexicaulis 467  
Isati.0297s0018.1.p PAC:39330613 Isatis tinctoria 312  
Sialb.0433s0012.1.p PAC:39565828 Sinapis alba 393  
Sialb.5617s0001.1.p PAC:39548969 Sinapis alba 468  
Stapi.8979s0001.1.p PAC:39826351 Stanleya pinnata 297  
Sialb.0143s0048.1.p PAC:45673703 Sinapis alba 393  
Sialb.0070s0338.1.p PAC:45618709 Sinapis alba 468  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1557023
            1560844