GO Term : GO:0003994 aconitate hydratase activity GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

42 Ontology Annotations

Class GO Term Gene Name Db
OntologyAnnotation GO:0003994 27625.m000051 GO
GOAnnotation GO:0003994 27625.t000003  
GOAnnotation GO:0003994 estExt_Genewise1Plus.C_20498  
OntologyAnnotation GO:0003994 27212 GO
GOAnnotation GO:0003994 MicpuC2.AZW_fgenesh1_pg.C_scaffold_14000103  
OntologyAnnotation GO:0003994 70903 GO
GOAnnotation GO:0003994 MicpuC2.estExt_Genewise1Plus.C_20328  
OntologyAnnotation GO:0003994 31433 GO
GOAnnotation GO:0003994 estExt_fgenesh2_kg.C_Chr_030014  
OntologyAnnotation GO:0003994 104770 GO
GOAnnotation GO:0003994 EuGene.0800010009  
OntologyAnnotation GO:0003994 60441 GO
GOAnnotation GO:0003994 eugene1.1.0200013050  
OntologyAnnotation GO:0003994 119573 GO
GOAnnotation GO:0003994 e_gwEuk.2.32.1  
OntologyAnnotation GO:0003994 35987 GO
OntologyAnnotation GO:0003994 Cre01.g042750.t1.2 GO
GOAnnotation GO:0003994 Cre01.g042750  
OntologyAnnotation GO:0003994 Dusal.0090s00020.1.p GO
GOAnnotation GO:0003994 Dusal.0090s00020  
GOAnnotation GO:0003994 ACO1  
OntologyAnnotation GO:0003994 Pum0176s0002.1.p GO
OntologyAnnotation GO:0003994 Pum0176s0002.2.p GO
GOAnnotation GO:0003994 Cz13g00140  
OntologyAnnotation GO:0003994 Cz13g00140.t1 GO
OntologyAnnotation GO:0003994 Thint.07G0604500.1.p GO
GOAnnotation GO:0003994 Thint.07G0604500  
GOAnnotation GO:0003994 Sapur.005G039000  
OntologyAnnotation GO:0003994 Sapur.005G039000.1.p GO
GOAnnotation GO:0003994 Acora.07G061900  

8 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016829 lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0016836 hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
GO:0003994 aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0016835 carbon-oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond.

17 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016836 GO:0003994
part of GO:0008150 GO:0003994
part of GO:0008152 GO:0003994
is_a GO:0003674 GO:0003994
is_a GO:0016835 GO:0003994
is_a GO:0016829 GO:0003994
is_a GO:0003824 GO:0003994
has_part GO:0003994 GO:0047780
has_part GO:0003994 GO:0052633
regulates GO:0003994 GO:1904232
regulates GO:0003994 GO:1904232
negatively regulates GO:0003994 GO:1904233
negatively regulates GO:0003994 GO:1904233
regulates GO:0003994 GO:1904233
positively regulates GO:0003994 GO:1904234
positively regulates GO:0003994 GO:1904234
regulates GO:0003994 GO:1904234

5 Synonyms

Name Type
citrate hydro-lyase activity synonym
cis-aconitase activity synonym
citrate(isocitrate) hydro-lyase (cis-aconitate-forming) synonym
citrate(isocitrate) hydro-lyase activity synonym
aconitase activity synonym