Protein Domain : IPR005775

Type:  Family Name:  P-type ATPase, subfamily IIC
Description:  Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. There are several different types of transmembrane ATPases, which can differ in function (ATP hydrolysis and/or synthesis), structure (e.g., F-, V- and A-ATPases, which contain rotary motors) and in the type of ions they transport [, ]. The different types include:F-ATPases (F1F0-ATPases), which are found in mitochondria, chloroplasts and bacterial plasma membranes where they are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases), which are primarily found in eukaryotic and they function as proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane []. They are also found in bacteria [].A-ATPases (A1A0-ATPases), which are found in Archaea and function like F-ATPases, though with respect to their structure and some inhibitor responses, A-ATPases are more closely related to the V-ATPases [, ].P-ATPases (E1E2-ATPases), which are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.E-ATPases, which are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.P-ATPases (also known as E1-E2 ATPases) () are found in bacteria and in a number of eukaryotic plasma membranes and organelles []. P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases, which transport specific types of ion: H+, Na+, K+, Mg2+, Ca2+, Ag+and Ag2+, Zn2+, Co2+, Pb2+, Ni2+, Cd2+, Cu+and Cu2+. P-ATPases can be composed of one or two polypeptides, and can usually assume two main conformations called E1 and E2.This entry represents the alpha subunit found in the P-type cation exchange ATPases located in the plasma membranes of animal cells. These P-ATPases include both H+/K+-ATPases () and Na+/K+-ATPases (), which belong to the IIC subfamily of ATPases [, ]. These ATPases catalyse the hydrolysis of ATP coupled with the exchange of cations, pumping one cation out of the cell (H+or Na+) in exchange for K+. These ATPases contain an alpha subunit that is the catalytic component, and a regulatory beta subunit () that stabilises the alpha/beta assembly []. Different alpha and beta isoforms exist, permitting greater regulatory control.An example of a H+/K+-ATPase is the gastric pump responsible for acid secretion in the stomach, transporting protons from the cytoplasm of parietal cells to create a large pH gradient in exchange for the internalisation of potassium ions, using ATP hydrolysis to drive the pump []. Short Name:  P-type_ATPase_IIC
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2 Child Features

DB identifier Type Name
IPR030333 Family Sodium/potassium-transporting ATPase subunit alpha-2
IPR030318 Family Potassium-transporting ATPase alpha chain 2

3 Contains

DB identifier Type Name
IPR006068 Domain Cation-transporting P-type ATPase, C-terminal
IPR004014 Domain Cation-transporting P-type ATPase, N-terminal
IPR018303 PTM P-type ATPase, phosphorylation site

1 Cross References

Identifier
TIGR01106

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0005391 IPR005775
GO:0005524 IPR005775
GO:0006813 IPR005775
GO:0006814 IPR005775
GO:0016021 IPR005775

5 Ontology Annotations

GO Term Gene Name
GO:0005391 IPR005775
GO:0005524 IPR005775
GO:0006813 IPR005775
GO:0006814 IPR005775
GO:0016021 IPR005775

1 Parent Features

DB identifier Type Name
IPR001757 Family P-type ATPase

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
48492 A4RQL0 PAC:27417508 Ostreococcus lucimarinus 1007  
Pum0108s0015.1.p A0A1X6PC70 PAC:38017403 Porphyra umbilicalis 1173  
Pum1746s0001.1.p A0A1X6NKV4 PAC:38014029 Porphyra umbilicalis 1174  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15473999
            15078220
            9741106
            20450191
            18937357
            1385979
            9419228
            7891030
            15096097
            10963432