Protein Domain : IPR030333

Type:  Family Name:  Sodium/potassium-transporting ATPase subunit alpha-2
Description:  Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) belongs to the IIC subfamily of P-type ATPases, whose members are sodium/potassium ATPases that catalyse the hydrolysis of ATP coupled with the transport of sodium/potassium across the membrane []. The functional enzyme is composed of a primary catalytic alpha subunit, a beta subunit, and, in some cells, an FXYD subunit. This entry represents subunit alpha-2, the major isoform of the alpha components [].Mutations in ATP1A2 cause familial hemiplegic migraine 2 (FHM2), a rare migraine subtype characterised by fully reversible motor weakness as a specific symptom of aura []. Short Name:  ATP1A2
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR24093:SF229

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0005391 IPR030333
GO:0005524 IPR030333
GO:0006813 IPR030333
GO:0006814 IPR030333
GO:0016021 IPR030333

5 Ontology Annotations

GO Term Gene Name
GO:0005391 IPR030333
GO:0005524 IPR030333
GO:0006813 IPR030333
GO:0006814 IPR030333
GO:0016021 IPR030333

1 Parent Features

DB identifier Type Name
IPR005775 Family P-type ATPase, subfamily IIC

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12539047
            23192345
            23918834