Protein Domain : IPR013132

Type:  Domain Name:  N-acetylneuraminic acid synthase, N-terminal
Description:  NeuB is the prokaryotic N-acetylneuraminic acid synthase. It catalyses the direct formation of N-acetylneuraminic acid (Neu5Ac), the most common sialic acid, by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). Mammals synthesise the 9-phosphate form, Neu5Ac-9-P, and utilise ManNAc-6-P instead of ManNAc [, , ]. The bacterial and mammalian enzymes share 30%-40% sequence identity and are composed of two distinct domains. The N-terminal domain (NeuB domain) consists of ~250 amino acid residues, and is considered to bind the sugar substrates. The C-terminal domain consists of ~75 amino acid residues, and is called the antifreeze-like (AFL) domain, since it is similar to those observed in a variety of functional type III antifreeze proteins (AFPs) [].This entry represents the N-terminal domain. Short Name:  Neu5Ac_N
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0 Child Features

0 Contains

1 Cross References

Identifier
PF03102

2 Found Ins

DB identifier Type Name
IPR020030 Family Pseudaminic acid biosynthesis, PseI
IPR020007 Family N-acetylneuraminate synthase

1 GO Annotation

GO Term Gene Name
GO:0016051 IPR013132

1 Ontology Annotations

GO Term Gene Name
GO:0016051 IPR013132

1 Parent Features

DB identifier Type Name
IPR013785 Domain Aldolase-type TIM barrel

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
89245 C1EJP0 PAC:27403019 Micromonas sp RCC299 348  
Brdisv1pangenome1007417m.p PAC:33607715 Brachypodium distachyon Pangenome 350  
Brdisv1pangenome1010959m.p PAC:33635465 Brachypodium distachyon Pangenome 336  
Brdisv1BdTR11A1042322m.p PAC:35696403 Brachypodium distachyon BdTR11a 582  
Brdisv1BdTR11A1041030m.p PAC:35687694 Brachypodium distachyon BdTR11a 595  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10873658
            15516336
            10749855
            15888312