Protein Domain : IPR015366

Type:  Domain Name:  Peptidase S53, propeptide
Description:  Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes []. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identified, these being grouped into clans on the basis of structural similarity and other functional evidence []. Structures are known for members of the clans and the structures indicate that some appear to be totally unrelated, suggesting different evolutionary origins for the serine peptidases [].Not withstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base []. The geometric orientations of the catalytic residues are similar between families, despite different protein folds []. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (PA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [, ].This domain is found at the N terminus of peptidases belonging to MEROPS peptidase family S53 (sedolisin, clan SB). The domain adopts a ferredoxin-like fold, with an alpha+beta sandwich. Cleavage of the domain results in activation of the peptidase []. Short Name:  Peptidase_S53_propep
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF09286
SM00944

1 Found In

DB identifier Type Name
IPR017001 Family Peptidase S53, physarolisin II, archaeal-type

1 GO Annotation

GO Term Gene Name
GO:0008236 IPR015366

1 Ontology Annotations

GO Term Gene Name
GO:0008236 IPR015366

1 Parent Features

DB identifier Type Name
IPR009020 Domain Proteinase inhibitor, propeptide

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
100010 C1E3R6 PAC:27400571 Micromonas sp RCC299 1386  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8439290
            7845208
            15242607