Protein Domain : IPR015643

Type:  Family Name:  Peptidase C1A, cathepsin B
Description:  Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad or triad []. This group of cysteine peptidases belong to MEROPS peptidase family C1, sub-family C1A (papain family, clan CA). It includes proteins classed as non-peptidase homologues. These are have either been shown experimentally to lack peptidase activity or lack one or more of the active site residues. This entry icludes cathepsin B and the CPC peptidases (cathepsin B-like) from Leishmania major, Leishmania mexicanaand Trypanosoma cruzi. Cathepsin B cysteine protease enzymes have been shown to be involved in a variety of different biological processes in eukaryotes. The isolation and characterisation of four distinct cathepsin B-like genes from Caenorhabditis eleganshas been reported []. Short Name:  Peptidase_C1A_cathepsin-B
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0 Child Features

3 Contains

DB identifier Type Name
IPR012599 Domain Peptidase C1A, propeptide
IPR000668 Domain Peptidase C1A, papain C-terminal
IPR000169 Active_site Cysteine peptidase, cysteine active site

2 Cross Referencess

Identifier
PTHR12411:SF16
PTHR12411:SF285

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0008234 IPR015643

1 Ontology Annotations

GO Term Gene Name
GO:0008234 IPR015643

1 Parent Features

DB identifier Type Name
IPR013128 Family Peptidase C1A

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
22888 C1N6V1 PAC:27348512 Micromonas pusilla CCMP1545 390  
193935 C1MUD6 PAC:27348044 Micromonas pusilla CCMP1545 475  
87440 C1EGF5 PAC:27402505 Micromonas sp RCC299 273  
94015 C1E4D9 PAC:27400266 Micromonas sp RCC299 359  
5520 A4SAY9 PAC:27420260 Ostreococcus lucimarinus 245  
94479 A4RYN2 PAC:27418352 Ostreococcus lucimarinus 330  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11517925
            8561899