Protein Domain : IPR008594

Type:  Family Name:  Scavenger mRNA decapping enzyme DcpS/DCS2
Description:  This entry represents scavenger mRNA decapping enzymes, such as Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrate to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP) []. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues []. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. This family is related to Short Name:  DcpS/DCS2
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0 Child Features

2 Contains

DB identifier Type Name
IPR011146 Domain HIT-like domain
IPR011145 Domain Scavenger mRNA decapping enzyme, N-terminal

3 Cross Referencess

Identifier
PTHR12978
PF05652
PIRSF028973

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0016787 IPR008594
GO:0000290 IPR008594

2 Ontology Annotations

GO Term Gene Name
GO:0016787 IPR008594
GO:0000290 IPR008594

0 Parent Features

10 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
18391 I0YQ43 PAC:27395058 Coccomyxa subellipsoidea C-169 284  
152650 C1MPA0 PAC:27347310 Micromonas pusilla CCMP1545 336  
99594 C1E275 PAC:27397999 Micromonas sp RCC299 341  
34772 A4S248 PAC:27413824 Ostreococcus lucimarinus 274  
Cre10.g432650.t1.1 A0A2K3D9Y9 PAC:30790796 Chlamydomonas reinhardtii 327  
Cz14g18030.t1 PAC:38243390 Chromochloris zofingiensis 87  
Cz14g18040.t1 PAC:38243548 Chromochloris zofingiensis 71  
Bobra.0022s0062.1.p PAC:40723251 Botryococcus braunii 316  
Cocit.L4519.1.p PAC:41062896 Corymbia citriodora 253  
Vocar.0019s0116.1.p PAC:32892611 Volvox carteri 308  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16246173
            16001405