Protein Domain : IPR010585

Type:  Family Name:  DNA repair protein XRCC4
Description:  This entry represents the DNA double-strand break repair and V(D)J recombination protein XRCC4, which is found in certain Metazoans, fungi and plants. XRCC4 binds to DNA, and to DNA ligase IV (LIG4) to form the LIG4-XRCC4 complex []. The LIG4-XRCC4 complex is responsible for the ligation step in the non-homologous end joining (NHEJ) pathway of DNA double-strand break repair. XRCC4 enhances the joining activity of LIG4. It is thought that XRCC4 and LIG4 are essential for alignment-based gap filling, as well as for final ligation of the breaks []. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Short Name:  DNA_repair_prot_XRCC4
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0 Child Features

2 Contains

DB identifier Type Name
IPR014751 Domain DNA repair protein XRCC4, C-terminal
IPR009089 Domain DNA double-strand break repair and VJ recombination XRCC4, N-terminal

1 Cross References

Identifier
PF06632

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR010585
GO:0006302 IPR010585
GO:0006310 IPR010585
GO:0005634 IPR010585

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR010585
GO:0006302 IPR010585
GO:0006310 IPR010585
GO:0005634 IPR010585

0 Parent Features

358 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_58.53 PAC:16423026 Carica papaya 224  
29844.m003159 B9RTD9 PAC:16810867 Ricinus communis 265  
Cucsa.218100.1 PAC:16969631 Cucumis sativus 233  
orange1.1g047048m A0A067DWF0 PAC:18108859 Citrus sinensis 240  
AT3G23100.2 Q682V0 PAC:19659415 Arabidopsis thaliana 264  
AT3G23100.1 Q682V0 PAC:19659414 Arabidopsis thaliana 264  
AT1G61410.1 Q058G5 PAC:19653105 Arabidopsis thaliana 118  
Thhalv10021924m V4LUQ6 PAC:20181447 Eutrema salsugineum 97  
Ciclev10005689m V4RZR5 PAC:20791586 Citrus clementina 256  
Ciclev10007171m V4RZS0 PAC:20791801 Citrus clementina 243  
Ciclev10005690m V4RZR0 PAC:20792097 Citrus clementina 256  
Lus10022210 PAC:23139465 Linum usitatissimum 266  
Lus10021220 PAC:23171381 Linum usitatissimum 264  
Potri.010G075900.1 A0A2K1YQH5 PAC:26978571 Populus trichocarpa 255  
Gorai.011G171700.1 A0A0D2VNB2 PAC:26812319 Gossypium raimondii 261  
67773 I0YMV9 PAC:27394408 Coccomyxa subellipsoidea C-169 326  
189372 C1N1K9 PAC:27340340 Micromonas pusilla CCMP1545 489  
63323 C1FIJ8 PAC:27399550 Micromonas sp RCC299 488  
Thecc1EG020798t1 A0A061ELJ5 PAC:27453448 Theobroma cacao 263  
Thecc1EG020798t3 A0A061ENI1 PAC:27453446 Theobroma cacao 277  
Thecc1EG020798t2 A0A061EM56 PAC:27453447 Theobroma cacao 276  
Migut.G00439.1.p A0A022R2F0 PAC:28943918 Mimulus guttatus 259  
Araha.5814s0002.1.p PAC:28844642 Arabidopsis halleri 264  
Glyma.10G184800.1.p I1LC95 PAC:30478120 Glycine max 256  
Glyma.20G205600.1.p I1NI57 PAC:30521199 Glycine max 256  
Brara.A02679.1.p A0A398AWF1 PAC:30638211 Brassica rapa FPsc 252  
Bradi1g09187.1.p PAC:31125374 Brachypodium distachyon 276  
Medtr1g075330.1 G7I3Z1 PAC:31096203 Medicago truncatula 256  
SapurV1A.0007s0640.1.p PAC:31413523 Salix purpurea 255  
Spipo9G0000200 PAC:31513799 Spirodela polyrhiza 234  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12517771
            11029705