| Type: | Repeat | Name: | NHL repeat, subgroup |
| Description: | The NHL repeat was defined by amino acid sequence homologies among Ncl-1, HT2A and Lin-41 proteins []. NHL is a conserved structural motif present in a large family of growth regulator. Many NHL containing proteins have additional domains such as a RING finger, a B-box zinc finger or a coiled-coil motif. According to structural model analysis the NHL domain could be involved in protein-protein interaction []. The NHL domain is a six-bladed beta-propeller, with the blades arrayed in a radial fashion around a central axis, and each blade composed of a highly twisted four stranded antiparallel beta-sheet []. The innermost strand of each blade is labeled 'a' and the outermost strand, 'd'. Like in other beta-propellers the sequence repeats are offset with respect to the blades of the propeller, such that any given 40-residue NHL repeat spans strands 'b-d' of one propellerblade and strand 'a' of the subsequent blade. This offset ensures circularization of the propeller because the last strand of the final sequence repeat acts as an innermost strand a of the blade that harbors strands 'b-d' from the first sequence repeat. | Short Name: | NHL_repeat_subgr |
