Type: | Family | Name: | Transcription elongation factor, TFIIS-related |
Description: | This entry represents transcription elongation factors of the IIS type. It also includes TFIIS-related proteins. TFIIS is a component of RNA polymerase II preinitiation complexes, and is required for preinitiation complex assembly and stability []. The association of TFIIS with a promoter depends on functional preinitiation complex components including Mediator and the SAGA complex []. TFIIS is composed of three domains: domain 1 forms a 4-helical bundle that appears to bind certain initiation factors; domain 2 forms a 3-helical bundle and is required for Pol II binding; domain 3 forms a zinc ribbon and is essential for stimulation of RNA cleavage [, ]. | Short Name: | TF_IIS-rel |