Protein Domain : IPR014640

Type:  Family Name:  Imidazole glycerol phosphate synthase HisHF
Description:  Members of this group are eukaryotic bifunctional enzymes with glutamine amidotransferase () and cyclase activities () that catalyse the fifth and sixth steps of the histidine biosynthetic pathway. In eubacteria, these steps are catalysed by a complex formed by two subunits, namely the glutamine amidotransferase HisH () and the cyclase HisF () which are encoded in the same operon [].The catalytic activity has been assessed for many members, mainly by complementation assays. The Saccharomyces cerevisiae(Baker s yeast) member is able to suppress His auxotrophy of corresponding Escherichia colihisH and hisF mutants []. In plants, hisHF cDNA from Emericella nidulans(Aspergillus nidulans) and Arabidopsis thaliana(Mouse-ear cress) complemented a S. cerevisiae his7Deltastrain [, ]. In addition, A. nidulans cDNA complemented E. coli hisHand hisFmutant strains []. Short Name:  IGPS_HisHF
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0 Child Features

2 Contains

DB identifier Type Name
IPR013785 Domain Aldolase-type TIM barrel
IPR011060 Domain Ribulose-phosphate binding barrel

1 Cross References

Identifier
PIRSF036936

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0000107 IPR014640
GO:0016763 IPR014640
GO:0016833 IPR014640
GO:0000105 IPR014640

4 Ontology Annotations

GO Term Gene Name
GO:0000107 IPR014640
GO:0016763 IPR014640
GO:0016833 IPR014640
GO:0000105 IPR014640

0 Parent Features

276 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Lus10032635 PAC:23146303 Linum usitatissimum 654  
Potri.009G061700.2 PAC:26988638 Populus trichocarpa 518  
Gorai.007G076800.4 A0A0D2SFW1 PAC:26782210 Gossypium raimondii 488  
28990 I0YZC3 PAC:27386594 Coccomyxa subellipsoidea C-169 582  
48216 C1N0H6 PAC:27340436 Micromonas pusilla CCMP1545 578  
87151 C1FJN8 PAC:27399931 Micromonas sp RCC299 601  
26336 A4S499 PAC:27420548 Ostreococcus lucimarinus 590  
Thecc1EG038034t2 A0A061GNK1 PAC:27430656 Theobroma cacao 600  
Thecc1EG038034t4 A0A061GM85 PAC:27430658 Theobroma cacao 542  
Thecc1EG038034t3 A0A061GV28 PAC:27430657 Theobroma cacao 557  
Migut.M01740.1.p A0A022QJA1 PAC:28948219 Mimulus guttatus 595  
Spipo20G0006900 PAC:31509598 Spirodela polyrhiza 555  
evm_27.model.AmTr_v1.0_scaffold00067.132 U5DBQ7 PAC:31561436 Amborella trichopoda 581  
Traes_4AS_E54C88DDB.4 PAC:31892101 Triticum aestivum 511  
Manes.03G132000.1.p A0A2C9W742 PAC:32363955 Manihot esculenta 594  
Manes.03G132000.2.p A0A2C9W732 PAC:32363956 Manihot esculenta 593  
Pahal.H02441.2 PAC:32507322 Panicum hallii 512  
Kalax.0014s0071.1.p PAC:32592093 Kalanchoe laxiflora 578  
Kalax.0372s0016.1.p PAC:32580873 Kalanchoe laxiflora 578  
Sphfalx0339s0007.1.p PAC:32608937 Sphagnum fallax 616  
Bradi1g67700.1.p I1H7B3 PAC:32801362 Brachypodium distachyon 569  
Pp3c1_20280V3.1.p A9S2M5 PAC:32969239 Physcomitrium patens 617  
Pp3c1_20280V3.2.p A9S2M5 PAC:32969240 Physcomitrium patens 617  
Mapoly0071s0086.1.p A0A2R6WNQ1 PAC:33008030 Marchantia polymorpha 599  
Dusal.0119s00020.1.p PAC:33195187 Dunaliella salina 577  
Brdisv1Per11011392m.p PAC:33230755 Brachypodium distachyon Per1 569  
Brdisv1Uni21010517m.p PAC:33270499 Brachypodium distachyon Uni2 569  
Brdisv1Bd3-1_r1008631m.p PAC:33305872 Brachypodium distachyon Bd3-1 569  
Brdisv1BdTR7a1011366m.p I1H7B3 PAC:33346877 Brachypodium distachyon BdTR7a 569  
Brdisv1Koz-11011291m.p PAC:33390797 Brachypodium distachyon Koz-1 569  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9654139
            8366040
            8852895
            11277623