GO Term : GO:0004663 Rab geranylgeranyltransferase activity GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

68 Ontology Annotations

Class GO Term Gene Name Db
GOAnnotation GO:0004663 evm.TU.supercontig_49.43  
OntologyAnnotation GO:0004663 evm.model.supercontig_49.43 GO
GOAnnotation GO:0004663 Lus10004165.g  
OntologyAnnotation GO:0004663 Lus10004165 GO
GOAnnotation GO:0004663 Gorai.008G270900  
OntologyAnnotation GO:0004663 Gorai.008G270900.3 GO
OntologyAnnotation GO:0004663 Gorai.008G270900.1 GO
OntologyAnnotation GO:0004663 Gorai.008G270900.4 GO
OntologyAnnotation GO:0004663 Gorai.008G270900.2 GO
GOAnnotation GO:0004663 Thecc1EG042402  
OntologyAnnotation GO:0004663 Thecc1EG042402t1 GO
GOAnnotation GO:0004663 Cagra.1508s0068  
OntologyAnnotation GO:0004663 Cagra.1508s0068.1.p GO
OntologyAnnotation GO:0004663 Glyma.05G000100.1.p GO
GOAnnotation GO:0004663 Glyma.05G000100  
GOAnnotation GO:0004663 Glyma.18G302200  
OntologyAnnotation GO:0004663 Glyma.18G302200.1.p GO
GOAnnotation GO:0004663 GSMUA_Achr8G11330_001  
OntologyAnnotation GO:0004663 GSMUA_Achr8P11330_001 GO
OntologyAnnotation GO:0004663 LOC_Os11g02980.1 GO
GOAnnotation GO:0004663 LOC_Os11g02980  
GOAnnotation GO:0004663 Zosma44g00570  
OntologyAnnotation GO:0004663 Zosma44g00570.1 GO
GOAnnotation GO:0004663 Brdisv1BdTR11I1045756m.g  
OntologyAnnotation GO:0004663 Brdisv1BdTR11I1045756m.p GO
GOAnnotation GO:0004663 PGSC0003DMG400020694  
OntologyAnnotation GO:0004663 PGSC0003DMP400035971 GO
OntologyAnnotation GO:0004663 Oeu053317.1 GO
GOAnnotation GO:0004663 Oeu053317.1  
OntologyAnnotation GO:0004663 Gohir.A12G251900.2.p GO

10 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0004659 prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor).
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
GO:0008318 protein prenyltransferase activity Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein.
GO:0004663 Rab geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0004661 protein geranylgeranyltransferase activity Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein.

9 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0004661 GO:0004663
is_a GO:0008318 GO:0004663
is_a GO:0003674 GO:0004663
is_a GO:0016740 GO:0004663
part of GO:0008150 GO:0004663
part of GO:0008152 GO:0004663
is_a GO:0016765 GO:0004663
is_a GO:0003824 GO:0004663
is_a GO:0004659 GO:0004663

7 Synonyms

Name Type
GGTase-II activity synonym
geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity synonym
protein geranylgeranyltransferase type II activity synonym
GGTaseII activity synonym
RabGGTase activity synonym
Rab-protein geranylgeranyltransferase activity synonym
type II protein geranyl-geranyltransferase activity synonym