Protein Domain : IPR015908

Type:  Domain Name:  Allantoicase domain
Description:  Allantoicase (also known as allantoate amidinohydrolase) is involved in purine degradation, facilitating the utilization of purines as secondary nitrogen sources under nitrogen-limiting conditions. While purine degradation converges to uric acid in all vertebrates, its further degradation varies from species to species. Uric acid is excreted by birds, reptiles, and some mammals that do not have a functional uricase gene, whereas other mammals produce allantoin. Amphibians and microorganisms produce ammonia and carbon dioxide using the uricolytic pathway. Allantoicase performs the second step in this pathway catalyzing the conversion of allantoate into ureidoglycolate and urea.allantoate + H(2)0 = (S)-ureidoglycolate + ureaThe structure of allantoicase is best described as being composed of two repeats (the allantoicase repeats: AR1 and AR2), which are connected by a flexible linker. The crystal structure, resolved at 2.4A resolution, reveals that AR1 has a very similar fold to AR2, both repeats being jelly-roll motifs, composed of four-stranded and five-stranded antiparallel beta-sheets []. Each jelly-roll motif has two conserved surface patches that probably constitute the active site []. The mammalian proteins matched by this entry are thought to be non-functional as mammals do not appear to possess allantoicase activity []. Short Name:  Allantoicase_dom
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0 Child Features

0 Contains

1 Cross References

Identifier
PF03561

1 Found In

DB identifier Type Name
IPR005164 Family Allantoicase

2 GO Annotations

GO Term Gene Name
GO:0004037 IPR015908
GO:0000256 IPR015908

2 Ontology Annotations

GO Term Gene Name
GO:0004037 IPR015908
GO:0000256 IPR015908

1 Parent Features

DB identifier Type Name
IPR008979 Domain Galactose-binding domain-like

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1007647m.p PAC:33622087 Brachypodium distachyon Pangenome 244  
Brdisv1pangenome1010929m.p PAC:33607850 Brachypodium distachyon Pangenome 264  
Brdisv1pangenome1011379m.p PAC:33621336 Brachypodium distachyon Pangenome 205  
Brdisv1BdTR11A1049036m.p PAC:35695757 Brachypodium distachyon BdTR11a 280  
Brdisv1BdTR11A1049541m.p PAC:35697014 Brachypodium distachyon BdTR11a 223  
Brdisv1BdTR11A1042650m.p PAC:35688107 Brachypodium distachyon BdTR11a 244  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15229895
            15020593
            11054555