Protein Domain : IPR005658

Type:  Family Name:  Proteinase inhibitor I11, ecotin
Description:  This entry represents proteinase inhibitors that belong to MEROPS inhibitor family I11, clan IN. Ecotins are dimeric periplasmic proteins from Escherichia coliand related Gram-negative bacteria that have been shown to be potent inhibitors of many trypsin-fold serine proteases of widely varying substrate specificity, which belong to MEROPS peptidase family S1 () []. Phylogenetic analysis suggested that ecotin has an exogenous target, possibly neutrophil elastase. Ecotin from E. coli, Yersinia pestis, and Pseudomonas aeruginosa, all species that encounter the mammalian immune system inhibit neutrophil elastase strongly while ecotin from the plant pathogen Pantoea citreainhibits neutrophil elastase 1000-fold less than the others [].They all potently inhibit pancreatic digestive peptidases trypsin and chymotrypsin, while showing more variable inhibition of the blood peptidases Factor Xa, thrombin, and urokinase-type plasminogen activator. Short Name:  Prot_inh_ecotin
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1 Child Features

DB identifier Type Name
IPR023084 Family Proteinase inhibitor I11, ecotin, gammaproteobacteria

0 Contains

1 Cross References

Identifier
PIRSF006865

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1006904m.p PAC:33655331 Brachypodium distachyon Pangenome 146  
Brdisv1pangenome1011193m.p PAC:33657948 Brachypodium distachyon Pangenome 158  
Brdisv1pangenome1010604m.p PAC:33658167 Brachypodium distachyon Pangenome 135  
Brdisv1BdTR11A1048643m.p PAC:35690118 Brachypodium distachyon BdTR11a 162  
Brdisv1BdTR11A1049330m.p PAC:35691265 Brachypodium distachyon BdTR11a 158  
Brdisv1BdTR11A1040094m.p PAC:35688140 Brachypodium distachyon BdTR11a 146  
Brdisv1BdTR11A1041256m.p PAC:35694362 Brachypodium distachyon BdTR11a 141  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14705960
            14705961