| Type: | Family | Name: | Proteinase inhibitor I11, ecotin, gammaproteobacteria |
| Description: | This entry represents bacterial proteinase inhibitors that belong to MEROPS inhibitor family I11, clan IN. Ecotins are dimeric periplasmic proteins from Escherichia coliand related Gram-negative bacteria that have been shown to be potent inhibitors of many trypsin-fold serine proteases of widely varying substrate specificity, which belong to MEROPS peptidase family S1 () []. Phylogenetic analysis suggested that ecotin has an exogenous target, possibly neutrophil elastase. Ecotin from E. coli, Yersinia pestis, and Pseudomonas aeruginosa, all species that encounter the mammalian immune system inhibit neutrophil elastase strongly while ecotin from the plant pathogen Pantoea citreainhibits neutrophil elastase 1000-fold less than the others [].Ecotin inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. | Short Name: | Prot_inh_ecotin_gammaproteobac |
