Protein Domain : IPR001807

Type:  Family Name:  Chloride channel, voltage gated
Description:  Chloride channels (CLCs) constitute an evolutionarily well-conserved family of voltage-gated channels that are structurally unrelated to the other known voltage-gated channels. They are found in organisms ranging from bacteria to yeasts and plants, and also to animals. Their functions in higher animals likely include the regulation of cell volume, control of electrical excitability and trans-epithelial transport [].The first member of the family (CLC-0) was expression-cloned from the electric organ of Torpedo marmorata [], and subsequently nine CLC-like proteins have been cloned from mammals. They are thought to function as multimers of two or more identical or homologous subunits, and they have varying tissue distributions and functional properties. To date, CLC-0, CLC-1, CLC-2, CLC-4 and CLC-5 have been demonstrated to form functional Cl- channels; whether the remaining isoforms do so is either contested or unproven. One possible explanation for the difficulty in expressing activatable Cl- channels is that some of the isoforms may function as Cl- channels of intracellular compartments, rather than of the plasma membrane. However, they are all thought to have a similar transmembrane (TM) topology, initial hydropathy analysis suggesting 13 hydrophobic stretches long enough to form putative TM domains []. Recently, the postulated TM topology has been revised, and it now seems likely that the CLCs have 10 (or possibly 12) TM domains, with both N- and C-termini residing in the cytoplasm [].A number of human disease-causing mutations have been identified in the genes encoding CLCs. Mutations in CLCN1, the gene encoding CLC-1, the major skeletal muscle Cl- channel, lead to both recessively and dominantly-inherited forms of muscle stiffness or myotonia []. Similarly, mutations in CLCN5, which encodes CLC-5, a renal Cl- channel, lead to several forms of inherited kidney stone disease []. These mutations have been demonstrated to reduce or abolish CLC function. Short Name:  Cl-channel_volt-gated
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13 Child Features

DB identifier Type Name
IPR002251 Family Chloride channel ClC-plant
IPR002246 Family Chloride channel ClC-4
IPR002245 Family Chloride channel ClC-3
IPR002248 Family Chloride channel ClC-6
IPR002247 Family Chloride channel ClC-5
IPR002242 Family Chloride channel ClC-0
IPR002244 Family Chloride channel ClC-2
IPR002243 Family Chloride channel ClC-1
IPR002249 Family Chloride channel ClC-7
IPR002250 Family Chloride channel ClC-K
IPR022969 Family Chloride channel YfeO
IPR023861 Family Chloride channel, ClcA
IPR023790 Family Chloride channel, voltage-gated, ClcB

2 Contains

DB identifier Type Name
IPR000644 Domain CBS domain
IPR014743 Domain Chloride channel, core

2 Cross Referencess

Identifier
PF00654
PR00762

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005247 IPR001807
GO:0006821 IPR001807
GO:0055085 IPR001807
GO:0016020 IPR001807

4 Ontology Annotations

GO Term Gene Name
GO:0005247 IPR001807
GO:0006821 IPR001807
GO:0055085 IPR001807
GO:0016020 IPR001807

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
101001 D8RTP5 PAC:15422275 Selaginella moellendorffii 510  
100906 D8RTA5 PAC:15403893 Selaginella moellendorffii 786  
442632 D8RUX8 PAC:15412332 Selaginella moellendorffii 773  
80232 D8QXY8 PAC:15403722 Selaginella moellendorffii 766  
80641 D8QXL5 PAC:15406821 Selaginella moellendorffii 773  
443196 D8RZE2 PAC:15411592 Selaginella moellendorffii 846  
420553 D8SCD2 PAC:15413754 Selaginella moellendorffii 737  
evm.TU.contig_29844.1 PAC:16429740 Carica papaya 769  
evm.TU.contig_35855.1 PAC:16430726 Carica papaya 132  
evm.model.supercontig_12.59 PAC:16406899 Carica papaya 778  
evm.model.supercontig_171.26 PAC:16410911 Carica papaya 790  
evm.model.supercontig_248.2 PAC:16414658 Carica papaya 756  
evm.model.supercontig_46.55 PAC:16420522 Carica papaya 779  
evm.model.supercontig_508.1 PAC:16421752 Carica papaya 177  
evm.model.supercontig_58.132 PAC:16422977 Carica papaya 421  
evm.model.supercontig_63.41 PAC:16424131 Carica papaya 196  
29844.m003366 B9RTZ4 PAC:16811072 Ricinus communis 794  
30162.m001267 B9RKW2 PAC:16820946 Ricinus communis 759  
30190.m010945 B9RBJ7 PAC:16823308 Ricinus communis 787  
30455.m000031 B9TGK6 PAC:16824434 Ricinus communis 233  
29609.m000610 B9SPD9 PAC:16803639 Ricinus communis 754  
27394.m000358 B9SXQ0 PAC:16798231 Ricinus communis 775  
28966.m000522 B9ST82 PAC:16802065 Ricinus communis 776  
Cucsa.041690.1 A0A0A0L4N0 PAC:16952814 Cucumis sativus 788  
Cucsa.087700.1 PAC:16956890 Cucumis sativus 852  
Cucsa.120040.1 PAC:16961069 Cucumis sativus 651  
Cucsa.120040.2 PAC:16961070 Cucumis sativus 651  
Cucsa.132420.1 I1Z8D0 PAC:16962559 Cucumis sativus 775  
Cucsa.185580.1 PAC:16967726 Cucumis sativus 797  
Cucsa.185580.4 PAC:16967729 Cucumis sativus 770  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9046241
            7581380
            2174129
            8559248
            9207144