Protein Domain : IPR004556

Type:  Family Name:  Modification methylase HemK
Description:  The gene hemK from Escherichia coliwas found to contribute to haem biosynthesis and originally suggested to be protoporphyrinogen oxidase []. Functional analysis of the nearest homologue in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologues have S-adenosyl-methionine-dependent methyltransferase activity []. Homologues are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both Escherichia coliand Haemophilus influenzaehave two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. Short Name:  Modification_methylase_HemK
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3 Child Features

DB identifier Type Name
IPR019874 Family Protein-(glutamine-N5) methyltransferase, release factor-specific
IPR017127 Family Ribosomal protein L3-specific, glutamine-N5-methyltransferase
IPR022446 Family Conserved hypothetical protein CHP03704, protein-(glutamine-N5) methyltransferase

2 Contains

DB identifier Type Name
IPR007848 Domain Methyltransferase small domain
IPR002052 Conserved_site DNA methylase, N-6 adenine-specific, conserved site

1 Cross References

Identifier
TIGR00536

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0008276 IPR004556
GO:0006479 IPR004556

2 Ontology Annotations

GO Term Gene Name
GO:0008276 IPR004556
GO:0006479 IPR004556

0 Parent Features

479 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
99812 D8RR86 PAC:15419536 Selaginella moellendorffii 336  
30150.m000481 B9SE56 PAC:16820656 Ricinus communis 354  
Cucsa.040400.1 PAC:16952767 Cucumis sativus 348  
orange1.1g020573m A0A067DN11 PAC:18123848 Citrus sinensis 324  
orange1.1g017476m A0A067DNF3 PAC:18123847 Citrus sinensis 371  
AT5G64150.1 Q9FMI5 PAC:19673092 Arabidopsis thaliana 377  
Thhalv10004403m V4KJX7 PAC:20200100 Eutrema salsugineum 379  
Ciclev10020646m V4VN10 PAC:20811704 Citrus clementina 374  
Lus10015342 PAC:23160874 Linum usitatissimum 366  
Potri.003G221400.1 A0A2K2BAW1 PAC:26998234 Populus trichocarpa 360  
Gorai.009G080200.2 A0A0D2TFW1 PAC:26763100 Gossypium raimondii 373  
Gorai.009G080200.1 A0A0D2TFW1 PAC:26763099 Gossypium raimondii 373  
35627 I0Z319 PAC:27389953 Coccomyxa subellipsoidea C-169 304  
126148 C1MLC9 PAC:27343190 Micromonas pusilla CCMP1545 423  
55214 C1FDW9 PAC:27398826 Micromonas sp RCC299 428  
24069 PAC:27414596 Ostreococcus lucimarinus 398  
119513 PAC:27414442 Ostreococcus lucimarinus 398  
Thecc1EG016738t2 A0A061G8D5 PAC:27447385 Theobroma cacao 394  
Thecc1EG016738t1 A0A061G8D5 PAC:27447384 Theobroma cacao 394  
Migut.M01570.1.p A0A022QIZ4 PAC:28950382 Mimulus guttatus 360  
Araha.11756s0382.1.p PAC:28856350 Arabidopsis halleri 245  
Araha.6840s0004.1.p PAC:28851604 Arabidopsis halleri 377  
Cagra.0248s0096.1.p PAC:28918841 Capsella grandiflora 377  
Glyma.08G167200.1.p K7L761 PAC:30535665 Glycine max 361  
Glyma.15G260100.1.p I1MJB2 PAC:30499281 Glycine max 364  
Brara.F02296.1.p A0A397Z0D8 PAC:30629392 Brassica rapa FPsc 375  
Bostr.0568s0389.1.p PAC:30669672 Boechera stricta 377  
Bradi4g01900.5.p PAC:31143564 Brachypodium distachyon 353  
Bradi4g01900.6.p PAC:31143565 Brachypodium distachyon 353  
Bradi4g01900.3.p PAC:31143562 Brachypodium distachyon 353  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7883187
            10220893