Protein Domain : IPR013709

Type:  Domain Name:  2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain
Description:  This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway []. This domain, is an internally duplicated structure with a novel fold []. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich []. Short Name:  2-isopropylmalate_synth_dimer
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF08502
SM00917
SSF110921

3 Found Ins

DB identifier Type Name
IPR005671 Family 2-isopropylmalate synthase, bacterial-type
IPR005675 Family Citramalate synthase
IPR005668 Family 2-isopropylmalate synthase

2 GO Annotations

GO Term Gene Name
GO:0003852 IPR013709
GO:0009098 IPR013709

2 Ontology Annotations

GO Term Gene Name
GO:0003852 IPR013709
GO:0009098 IPR013709

0 Parent Features

683 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
97271 D8RMD1 PAC:15409249 Selaginella moellendorffii 549  
111991 D8S9Y1 PAC:15414425 Selaginella moellendorffii 610  
evm.model.supercontig_71.35 PAC:16425443 Carica papaya 504  
30041.m000240 B9SX30 PAC:16816031 Ricinus communis 632  
34620.m000030 B9TL14 PAC:16826288 Ricinus communis 124  
Cucsa.012740.2 PAC:16951558 Cucumis sativus 604  
Cucsa.012740.3 PAC:16951559 Cucumis sativus 592  
Cucsa.012740.1 PAC:16951557 Cucumis sativus 633  
orange1.1g006969m PAC:18137795 Citrus sinensis 623  
orange1.1g007056m A0A067DEB3 PAC:18137796 Citrus sinensis 620  
AT1G18500.1 Q9LPR4 PAC:19653246 Arabidopsis thaliana 631  
AT1G74040.1 Q9C550 PAC:19651597 Arabidopsis thaliana 631  
Thhalv10007073m V4MT15 PAC:20185552 Eutrema salsugineum 625  
Thhalv10018267m V4M9C9 PAC:20192296 Eutrema salsugineum 631  
Ciclev10020218m V4T7V3 PAC:20809584 Citrus clementina 433  
Lus10019574 PAC:23169901 Linum usitatissimum 234  
Potri.005G083100.3 PAC:27028692 Populus trichocarpa 570  
Potri.005G083100.1 A0A2K2ADH3 PAC:27028689 Populus trichocarpa 593  
Potri.005G083100.2 A0A2K2ADH3 PAC:27028691 Populus trichocarpa 593  
Potri.005G083100.4 A0A2K2ADH3 PAC:27028690 Populus trichocarpa 593  
Gorai.005G127500.1 A0A0D2SFQ2 PAC:26804575 Gossypium raimondii 623  
Gorai.011G145600.1 A0A0D2T873 PAC:26808234 Gossypium raimondii 627  
53294 I0Z115 PAC:27390928 Coccomyxa subellipsoidea C-169 599  
36068 C1N4J5 PAC:27339860 Micromonas pusilla CCMP1545 649  
47814 C1MYB9 PAC:27339191 Micromonas pusilla CCMP1545 757  
96641 C1FHL1 PAC:27397378 Micromonas sp RCC299 662  
96632 C1FID7 PAC:27397527 Micromonas sp RCC299 639  
29150 A4RRV6 PAC:27417763 Ostreococcus lucimarinus 624  
Thecc1EG020103t1 A0A061EKQ4 PAC:27455335 Theobroma cacao 657  
Thecc1EG020103t2 A0A061EJX2 PAC:27455336 Theobroma cacao 624  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15159544