| Type: | Domain | Name: | NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit |
| Description: | This domain is found in subunits NuoL/ND5, NuoM/ND4, and NuoN/ND2 of the NADH:quinone oxidoreductase (complex I), Mrp antiporters subunits A and D, and in membrane subunits of hydrogenase complexes, such as hydrogenase-4 and F420H2 dehydrogenase.Mrp-type antiporters comprise the cation/proton antiporter family 3 (CPA3), commonly referred to as Mrp. They are the products of operons that carry either six or seven genes (mrpA-G), and form complexes containing all subunits [, ]. They have Na(+)/H(+) antiporter activity []. Two of the Mrp proteins, MrpA and MrpD, resemble NuoL/ND5, NuoM/ND4, NuoN/ND2, the homologous subunits that constitute the membrane-embedded, proton-translocating core of complex I [, , , ]. They also resemble subunits of membrane-bound hydrogenases, such as HyfB, HyfD and HyfF from E.coli [] and F420H2 dehydrogenasa (FPO complex) subunits L, N and M []. | Short Name: | ND/Mrp_mem |
| DB identifier | Type | Name |
|---|---|---|
| IPR003945 | Family | NADH-plastoquinone oxidoreductase, chain 5 |
| IPR018393 | Family | NADH-plastoquinone oxidoreductase, chain 5 subgroup |
| IPR010227 | Family | NADH-quinone oxidoreductase, chain M/4 |
| IPR003918 | Family | NADH:ubiquinone oxidoreductase |
| IPR010096 | Family | NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 |
| IPR003917 | Family | NADH:ubiquinone oxidoreductase, chain 2 |
| IPR004775 | Family | Na(+)/H(+) antiporter subunit D1 |
| IPR010217 | Family | NAD(P)H dehydrogenase, subunit NdhF3 |
