Protein Domain : IPR007264

Type:  Family Name:  H/ACA ribonucleoprotein complex, subunit Nop10
Description:  H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. More than 100 mammalian H/ACA RNAs form an equal number of ribonucleoproteins (RNPs) by associating with the same four core proteins: Cbf5, Gar1, Nhp2 and Nop10. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes []. Recent crystal structures of archaeal H/ACA protein complexes show how the same four proteins accommodate >100 distinct but related H/ACA RNAs []. The complex contains a stable core composed of Cbf5 and Nop10, to which Gar1 and Nhp2 subsequently bind, the complex interacts with snoRNAs [].In eukaryotes Nop10 is a nucleolar protein that is specifically associated with H/ACA snoRNAs. It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA snoRNAs (H/ACA snoRNPs). Nop10 is probably necessary for the stability of these RNPs []. Short Name:  H/ACA_rnp_Nop10
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1 Child Features

DB identifier Type Name
IPR023532 Family H/ACA ribonucleoprotein complex subunit Nop10 , archaeal-type

0 Contains

3 Cross Referencess

Identifier
PTHR13305
PF04135
SSF144210

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0030515 IPR007264
GO:0001522 IPR007264
GO:0042254 IPR007264
GO:0072588 IPR007264

4 Ontology Annotations

GO Term Gene Name
GO:0030515 IPR007264
GO:0001522 IPR007264
GO:0042254 IPR007264
GO:0072588 IPR007264

0 Parent Features

425 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
229746 D8TCE0 PAC:15412956 Selaginella moellendorffii 64  
28492.m000485 B9SV31 PAC:16800965 Ricinus communis 64  
Cucsa.171640.1 PAC:16966521 Cucumis sativus 102  
AT2G20490.1 Q93XX8 PAC:19643246 Arabidopsis thaliana 64  
AT2G20490.2 F4IVE5 PAC:19643247 Arabidopsis thaliana 63  
Thhalv10002146m V4NUH8 PAC:20200421 Eutrema salsugineum 64  
Thhalv10002145m V4NUH8 PAC:20200422 Eutrema salsugineum 64  
Thhalv10002147m V4NUH8 PAC:20200423 Eutrema salsugineum 64  
Thhalv10002149m V4LIR1 PAC:20200424 Eutrema salsugineum 63  
Ciclev10023246m V4TU81 PAC:20810053 Citrus clementina 64  
Lus10033907 PAC:23172881 Linum usitatissimum 64  
Lus10024913 PAC:23178904 Linum usitatissimum 64  
Lus10022910 PAC:23159945 Linum usitatissimum 121  
Potri.002G036500.3 A9PC09 PAC:27020443 Populus trichocarpa 64  
Potri.002G036500.1 A9PC09 PAC:27020441 Populus trichocarpa 64  
Potri.002G036500.2 A9PC09 PAC:27020442 Populus trichocarpa 64  
Potri.002G036500.4 A9PC09 PAC:27020440 Populus trichocarpa 64  
Potri.005G226300.1 A9PCI2 PAC:27028933 Populus trichocarpa 64  
Potri.005G226300.2 A9PCI2 PAC:27028932 Populus trichocarpa 64  
Gorai.010G167900.2 A0A0D2R930 PAC:26756280 Gossypium raimondii 64  
Gorai.010G167900.3 A0A0D2R930 PAC:26756279 Gossypium raimondii 64  
Gorai.010G167900.1 A0A0D2VBC4 PAC:26756278 Gossypium raimondii 86  
Gorai.011G047500.1 A0A0D2ULR9 PAC:26812254 Gossypium raimondii 64  
86098 C1EE84 PAC:27405135 Micromonas sp RCC299 64  
31537 A4RX20 PAC:27416632 Ostreococcus lucimarinus 61  
Thecc1EG029425t1 A0A061GKM2 PAC:27440790 Theobroma cacao 139  
Migut.N02211.1.p A0A022PQE1 PAC:28923295 Mimulus guttatus 64  
Migut.N02442.1.p A0A022RAS9 PAC:28923765 Mimulus guttatus 134  
Cagra.2516s0026.1.p PAC:28900715 Capsella grandiflora 64  
Glyma.03G164500.1.p A0A0R4J2W3 PAC:30516901 Glycine max 64  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16943774
            16647858
            19917616
            9843512