Protein Domain : IPR017896

Type:  Domain Name:  4Fe-4S ferredoxin-type, iron-sulphur binding domain
Description:  Ferredoxins are a group of iron-sulphur proteins which mediate electron transfer in a wide variety of metabolic reactions. Ferredoxins can be divided into several subgroups depending upon the physiological nature of the iron-sulphur cluster(s). One of these subgroups are the 4Fe-4S ferredoxins, which are found in bacteria and which are thus often referred as 'bacterial-type' ferredoxins. The structure of these proteins [] consists of the duplication of a domain of twenty six amino acid residues; each of these domains contains four cysteine residues that bind to a 4Fe-4S centre.Several structures of the 4Fe-4S ferredoxin domain have been determined []. The clusters consist of two interleaved 4Fe- and 4S-tetrahedra forming a cubane-like structure, in such a way that the four iron occupy the eight corners of a distorted cube. Each 4Fe-4S is attached to the polypeptide chain by four covalent Fe-S bonds involving cysteine residues.A number of proteins have been found [] that include one or more 4Fe-4S binding domains similar to those of bacterial-type ferredoxins.The pattern of cysteine residues in the iron-sulphur region is sufficient to detect this class of 4Fe-4S binding proteins. This entry represents the whole domain.Note:In some bacterial ferredoxins, one of the two duplicated domains has lost one or more of the four conserved cysteines. The consequence of such variations is that these domains have either lost their iron-sulphur binding property or bind to a 3Fe-3S centre instead of a 4Fe-4S centre. Short Name:  4Fe4S_Fe-S-bd
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0 Child Features

1 Contains

DB identifier Type Name
IPR017900 Conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site

13 Cross Referencess

Identifier
PF00037
PF12797
PF12798
PF12800
PF12801
PF12837
PF12838
PF13183
PF13187
PF13237
PF13247
PF13746
PS51379

8 Found Ins

DB identifier Type Name
IPR017491 Family Photosystem I protein PsaC
IPR013283 Family ABC transporter ABCE
IPR006006 Family Glutamate synthase, NADH/NADPH, small subunit 2
IPR017701 Family Putative selenate reductase YgfK
IPR012206 Family Ferredoxin-like, FixX
IPR011399 Family Nitrous oxide reductase expression regulator NosR
IPR017680 Family CoB--CoM heterodisulphide reductase, subunit C
IPR011806 Family Sulphite reductase, dissimilatory-type alpha subunit

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
136585 D8TBZ5 PAC:15417938 Selaginella moellendorffii 193  
108358 D8S3V0 PAC:15422830 Selaginella moellendorffii 217  
57580 D8S953 PAC:15405008 Selaginella moellendorffii 234  
82638 D8R0V1 PAC:15412741 Selaginella moellendorffii 258  
118126 D8SIL6 PAC:15406153 Selaginella moellendorffii 248  
422906 D8SJY1 PAC:15422378 Selaginella moellendorffii 215  
85593 D8R553 PAC:15420861 Selaginella moellendorffii 248  
86191 D8R556 PAC:15420709 Selaginella moellendorffii 248  
evm.model.supercontig_130.56 PAC:16407962 Carica papaya 281  
evm.model.supercontig_17.25 PAC:16410745 Carica papaya 499  
evm.model.supercontig_283.8 PAC:16416051 Carica papaya 305  
evm.model.supercontig_352.3 PAC:16418237 Carica papaya 519  
evm.model.supercontig_52.156 PAC:16422016 Carica papaya 278  
evm.model.supercontig_62.151 PAC:16423952 Carica papaya 222  
evm.model.supercontig_63.22 PAC:16424110 Carica papaya 81  
evm.model.supercontig_9.57 PAC:16428323 Carica papaya 307  
29756.m000511 B9SQL2 PAC:16807974 Ricinus communis 591  
29872.m000534 B9SQB4 PAC:16811929 Ricinus communis 107  
29889.m003299 B9RZQ9 PAC:16812246 Ricinus communis 421  
29933.m001403 B9SF93 PAC:16814131 Ricinus communis 301  
30190.m010898 B9RBF2 PAC:16823262 Ricinus communis 222  
31270.m000029 B9TI75 PAC:16824915 Ricinus communis 87  
31326.m000015 B9TCR2 PAC:16824948 Ricinus communis 588  
29633.m000905 B9SLS5 PAC:16804165 Ricinus communis 284  
28629.m000572 B9SWH6 PAC:16801327 Ricinus communis 1092  
28629.m000571 B9SWH5 PAC:16801326 Ricinus communis 1153  
28745.m000035 B9T7U2 PAC:16801628 Ricinus communis 313  
27401.m000275 B9SZP0 PAC:16798246 Ricinus communis 309  
28069.m000039 B9TCF0 PAC:16799858 Ricinus communis 83  
28738.m000147 B9SW34 PAC:16801619 Ricinus communis 334  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2185975
            7966291
            3129571