Protein Domain : IPR017680

Type:  Family Name:  CoB--CoM heterodisulphide reductase, subunit C
Description:  This entry represents subunit C (HdrC) from CoB--CoM heterodisulphide reductase (or heterodisulphide reductase; Hdr; ), an iron-sulphur protein found in methanogenic archaea []. Hdr catalyses the reversible reduction of the heterodisulphide (CoM-S-S-CoB) to the thiol-coenzymes: coenzyme M (H-S-CoM) and coenzyme B (H-S-CoB). Hdr is composed of three subunits: hdrA (subunit A), hdrB (subunit B) and hdrC (subunit C). Hdr forms a complex with the F420-non-reducing hydrogenase (Mvh), which provides the reducing equivalents to the heterodisulphide reductase.All processes in methanogenesis lead to the formation of a mixed disulphide bond between coenzyme-M and coenzyme-B, by a reaction in which coenzyme B reduces methyl-CoM, leading to formation of methane and a CoB-CoM heterodisulphide []. There are two different systems that are capable of reducing the CoB-CoM heterodisulphide, using either H2 or a reduced cofactor F420 as electron donors [].HdrC may carry electrons from hydrogenase to hdrA. Similar enzyme complex subunits are found in various other species, but likely act on a different substrate. Short Name:  CoB/CoM_hetero-S_Rdtase_csu
Paste the following link

0 Child Features

2 Contains

DB identifier Type Name
IPR017896 Domain 4Fe-4S ferredoxin-type, iron-sulphur binding domain
IPR017900 Conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site

1 Cross References

Identifier
TIGR03290

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0051539 IPR017680
GO:0051912 IPR017680
GO:0015948 IPR017680
GO:0051186 IPR017680
GO:0055114 IPR017680

5 Ontology Annotations

GO Term Gene Name
GO:0051539 IPR017680
GO:0051912 IPR017680
GO:0015948 IPR017680
GO:0051186 IPR017680
GO:0055114 IPR017680

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12102556
            11322875
            15168610