Protein Domain : IPR000536

Type:  Domain Name:  Nuclear hormone receptor, ligand-binding domain
Description:  Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences (), connected via a linker region to a C-terminal ligand-binding domain. In addition, certain nuclear hormone receptors have an N-terminal modulatory domain (). The ligand-binding domain acts in response to ligand binding, which caused a conformational change in the receptor to induce a response, thereby acting as a molecular switch to turn on transcriptional activity []. For example, after binding of the glucocorticoid receptor to the corticosteroid ligand, the receptor is induced to perform functions ranging from nuclear translocation, oligomerisation, cofactor/kinase/transcription factor association, and DNA binding []. The ligand-binding domain is a flexible unit, where the binding of a ligand stabilises its conformation, which in turn favours coactivator binding to modify receptor activity []; the coactivator can bind to the activator function 2 (AF2) site at the C-terminal end of the ligand-binding domain []. The binding of different ligands can alter the conformation of the ligand-binding domain, which ultimately affects the DNA-binding specificity of the DNA-binding domain. In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components.This entry represents the all helical domain involved in ligand-binding. Short Name:  Nucl_hrmn_rcpt_lig-bd
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0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF00104
SM00430
G3DSA:1.10.565.10
SSF48508

15 Found Ins

DB identifier Type Name
IPR003071 Family Orphan nuclear receptor, HMR type
IPR003073 Family Orphan nuclear receptor, NURR type
IPR016355 Family Nuclear hormone receptor family 5
IPR001723 Family Nuclear hormone receptor
IPR000003 Family Retinoid X receptor/HNF4
IPR001728 Family Thyroid hormone receptor
IPR003068 Family Transcription factor COUP
IPR003069 Family Ecdysteroid receptor
IPR003070 Family Orphan nuclear receptor
IPR003074 Family Peroxisome proliferator-activated receptor
IPR003075 Family Peroxisome proliferator-activated receptor, beta
IPR003076 Family Peroxisome proliferator-activated receptor, alpha
IPR003077 Family Peroxisome proliferator-activated receptor, gamma
IPR003078 Family Retinoic acid receptor
IPR003079 Family Nuclear receptor ROR

2 GO Annotations

GO Term Gene Name
GO:0006355 IPR000536
GO:0043401 IPR000536

2 Ontology Annotations

GO Term Gene Name
GO:0006355 IPR000536
GO:0043401 IPR000536

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410579 D8RF69 PAC:15406465 Selaginella moellendorffii 512  
404120 D8QUC2 PAC:15407734 Selaginella moellendorffii 194  
420856 D8SDC2 PAC:15416026 Selaginella moellendorffii 401  
evm.TU.contig_37107.1 PAC:16430987 Carica papaya 189  
evm.model.supercontig_101.33 PAC:16404790 Carica papaya 274  
evm.model.supercontig_1789.2 PAC:16411181 Carica papaya 162  
evm.model.supercontig_33.30 PAC:16417672 Carica papaya 124  
29739.m003577 B9RQS6 PAC:16807357 Ricinus communis 139  
30005.m001277 B9SF24 PAC:16815509 Ricinus communis 586  
30111.m000738 B9SK54 PAC:16817895 Ricinus communis 137  
29633.m000908 B9SLS8 PAC:16804168 Ricinus communis 582  
29586.m000600 B9SPY5 PAC:16803180 Ricinus communis 74  
Cucsa.369500.1 PAC:16981742 Cucumis sativus 307  
Cucsa.120150.1 PAC:16961100 Cucumis sativus 575  
Cucsa.156240.1 A0A0A0L8E4 PAC:16964859 Cucumis sativus 589  
Cucsa.252770.5 PAC:16971988 Cucumis sativus 323  
Cucsa.252770.1 PAC:16971984 Cucumis sativus 428  
Cucsa.252770.4 PAC:16971987 Cucumis sativus 419  
orange1.1g035205m A0A067FYJ6 PAC:18135252 Citrus sinensis 70  
orange1.1g013454m A0A067F1G0 PAC:18103387 Citrus sinensis 442  
orange1.1g036367m A0A067EQ68 PAC:18128362 Citrus sinensis 198  
orange1.1g046948m A0A067E676 PAC:18105082 Citrus sinensis 315  
AT5G12420.1 Q94CK0 PAC:19671256 Arabidopsis thaliana 480  
AT2G15440.1 Q9SJN8 PAC:19638487 Arabidopsis thaliana 329  
Thhalv10022776m V4MET7 PAC:20201866 Eutrema salsugineum 329  
Thhalv10004240m V4KZ51 PAC:20198177 Eutrema salsugineum 438  
Ciclev10001436m V4SXG6 PAC:20786208 Citrus clementina 390  
Ciclev10001579m V4T7G1 PAC:20786209 Citrus clementina 367  
Ciclev10026534m V4S1D0 PAC:20801304 Citrus clementina 198  
Ciclev10005465m V4RMF5 PAC:20791023 Citrus clementina 315  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14973393
            15193451
            15661830
            15728727