Protein Domain : IPR001723

Type:  Family Name:  Nuclear hormone receptor
Description:  Steroid or nuclear hormone receptors (4A nuclear receptor, NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands []. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner [, ]. In addition to C-terminal ligand-binding domains, these nuclear receptors contain a highly-conserved, N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements. In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research, a large number of them being implicated in diseases such as cancer, diabetes, hormone resistance syndromes, etc. While several NRs act as ligand-inducible transcription factors, many do not yet have a defined ligand and are accordingly termed 'orphan' receptors. During the last decade, more than 300 NRs have been described, many of which are orphans, which cannot easily be named due to current nomenclature confusions in the literature. However, a new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members. Short Name:  Nuclear_hrmn_rcpt
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14 Child Features

DB identifier Type Name
IPR016355 Family Nuclear hormone receptor family 5
IPR024178 Family Oestrogen receptor/oestrogen-related receptor
IPR000128 Family Progesterone receptor
IPR000003 Family Retinoid X receptor/HNF4
IPR000324 Family Vitamin D receptor
IPR001728 Family Thyroid hormone receptor
IPR003068 Family Transcription factor COUP
IPR003069 Family Ecdysteroid receptor
IPR003070 Family Orphan nuclear receptor
IPR003074 Family Peroxisome proliferator-activated receptor
IPR003078 Family Retinoic acid receptor
IPR003079 Family Nuclear receptor ROR
IPR001409 Family Glucocorticoid receptor
IPR023257 Family Liver X receptor

1 Contains

DB identifier Type Name
IPR000536 Domain Nuclear hormone receptor, ligand-binding domain

1 Cross References

Identifier
PR00398

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR001723
GO:0003707 IPR001723
GO:0006355 IPR001723
GO:0005634 IPR001723

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR001723
GO:0003707 IPR001723
GO:0006355 IPR001723
GO:0005634 IPR001723

0 Parent Features

0 Proteins

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7899080
            8165128
            14747695