Protein Domain : IPR016439

Type:  Family Name:  Ceramide synthase component Lag1/Lac1
Description:  Yeast ceramide synthase component Lag1 has a a paralog, Lac1. This entry includes Lac1, Lag1 and their homologues from plants and animals [, ]. They may be involved in sphingolipid synthesis.LAG1 and LAC1 contain multiple membrane-spanning domains and are localised to the endoplasmic reticulum (ER) []. They are essential subunits of the acyl-CoA-dependent ceramide synthase that is involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine [, , ].Human Lac1/Lag1 homologue CERS2 (ceramide synthase 2) is a tumour metastasis suppressor that can inhibit breast cancer cell invasion []. Tomato Lac1/Lag1 homologue ASC1 can mediate resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis []. Short Name:  Lag1/Lac1
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0 Child Features

2 Contains

DB identifier Type Name
IPR006634 Domain TRAM/LAG1/CLN8 homology domain
IPR013599 Domain TRAM1-like protein

2 Cross Referencess

Identifier
PTHR12560
PIRSF005225

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0005783 IPR016439
GO:0016021 IPR016439

2 Ontology Annotations

GO Term Gene Name
GO:0005783 IPR016439
GO:0016021 IPR016439

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
78320 D8QUF1 PAC:15420717 Selaginella moellendorffii 322  
420762 D8SD13 PAC:15415280 Selaginella moellendorffii 308  
170071 D8RDJ6 PAC:15402951 Selaginella moellendorffii 294  
evm.model.supercontig_53.9 PAC:16422318 Carica papaya 308  
evm.model.supercontig_62.10 PAC:16423895 Carica papaya 326  
29801.m003184 B9RYI1 PAC:16809034 Ricinus communis 315  
30138.m003858 B9RLC5 PAC:16819228 Ricinus communis 64  
30174.m009049 B9RE82 PAC:16822690 Ricinus communis 308  
36771.m000012 B9TAI2 PAC:16826964 Ricinus communis 265  
Cucsa.219880.1 A0A0A0K373 PAC:16969872 Cucumis sativus 289  
Cucsa.374410.1 A0A0A0KQ09 PAC:16981911 Cucumis sativus 308  
orange1.1g043282m A0A067D461 PAC:18115698 Citrus sinensis 119  
orange1.1g026454m PAC:18121617 Citrus sinensis 238  
orange1.1g026084m PAC:18121616 Citrus sinensis 243  
orange1.1g027101m PAC:18121618 Citrus sinensis 228  
orange1.1g029440m A0A067FS66 PAC:18121619 Citrus sinensis 193  
orange1.1g021716m PAC:18121613 Citrus sinensis 308  
orange1.1g021748m PAC:18121614 Citrus sinensis 308  
orange1.1g022681m PAC:18121615 Citrus sinensis 293  
orange1.1g046165m A0A067F967 PAC:18100206 Citrus sinensis 287  
orange1.1g044744m A0A067FR06 PAC:18133635 Citrus sinensis 258  
orange1.1g047636m A0A067FQ93 PAC:18133602 Citrus sinensis 238  
AT3G19260.1 Q9LJK3 PAC:19664289 Arabidopsis thaliana 296  
AT3G25540.1 Q9LDF2 PAC:19659539 Arabidopsis thaliana 310  
AT1G26200.1 F4IE43 PAC:19650675 Arabidopsis thaliana 312  
AT1G13580.1 Q6NQI8 PAC:19656659 Arabidopsis thaliana 239  
AT1G13580.3 Q6NQI8 PAC:19656658 Arabidopsis thaliana 308  
AT1G13580.2 Q6NQI8 PAC:19656657 Arabidopsis thaliana 308  
Thhalv10021239m V4LZN2 PAC:20183279 Eutrema salsugineum 297  
Thhalv10008348m V4KZJ8 PAC:20185339 Eutrema salsugineum 293  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11694577
            10198056
            15692566
            15236759
            12105227
            12445127
            25213553