| Type: | Family | Name: | Phenol hydroxylase reductase |
| Description: | Flavoprotein pyridine nucleotide cytochrome reductases [] (FPNCR) catalysethe interchange of reducing equivalents between one-electron carriers and the two-electron-carrying nicotinamide dinucleotides. The enzymes includeferredoxin:NADP+ reductases (FNR); plant and fungal NAD(P)H:nitrate reductases; NADH:cytochrome b5 reductases; NADPH:P450 reductases;NADPH:sulphite reductases; nitric oxide synthases; phthalate dioxygenase reductase; and various other flavoproteins.Dioxygen can be incorporated directly into organic compounds in reactionscatalysed by enzymes termed oxygenases or hydroxylases: oxygenases that catalyse the incorporation of both atoms of dioxygen into substrates areknown as dioxygenases; those that catalyse the incorporation of only one atom of dioxygen are termed monooxygenases, or mixed-function oxygenases.The second atom of dioxygen is reduced to H2O either by the substrates themselves or by a co-substrate reductant [].Electron transfer components of a number of bacterial multi-component aromatic-ring and alkyl-group oxygenases (including phenol hydroxylase [],benzoate 1,2-dioxygenase [], toluate 1,2-dioxygenase [], xylene monooxygenase [] and methane monooxygenase []), belong to family of [2Fe-2S] ferredoxin/FPNCR fusion proteins. Other members of the family are Yersinia pseudotuberculosis CDP-6-deoxy-3,4-glucoseen reductase [] and S.typhimurium rfbI protein []. All contain a [2Fe-2S]ferredoxin domain fused to the N terminus of an FPNCR domain. The direction of electron flowis from flavin to the [2Fe-2S] centre.Phenol hydroxylase [], benzoate-1,2-dioxygenase [],toluate-1,2-dioxygenase [], xylene monooxygenase [] and methane monooxygenase [] contain an oxidoreductase FAD/NAD(P)-binding domain. They are the electron transfer components of a number of bacterial multi-component aromatic-ring and alkyl-group oxygenases. | Short Name: | Phe_hydroxylase |
| DB identifier | Type | Name |
|---|---|---|
| IPR012675 | Domain | Beta-grasp domain |
| IPR001041 | Domain | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| IPR001709 | Domain | Flavoprotein pyridine nucleotide cytochrome reductase |
| IPR017938 | Domain | Riboflavin synthase-like beta-barrel |
| IPR001433 | Domain | Oxidoreductase FAD/NAD(P)-binding |
| IPR017927 | Domain | Ferredoxin reductase-type FAD-binding domain |
| IPR008333 | Domain | Oxidoreductase, FAD-binding domain |
