Protein Domain : IPR022663

Type:  Domain Name:  Dihydrodipicolinate reductase, C-terminal
Description:  This entry represents the C-terminal region of Dihydrodipicolinate reductase.Dihydrodipicolinate reductase catalyzes the second step in the biosynthesis of diaminopimelic acid and lysine, the NAD or NADP-dependent reduction of 2,3-dihydrodipicolinate into 2,3,4,5-tetrahydrodipicolinate [, , ].In Escherichia coliand Mycobacterium tuberculosis, dihydrodipicolinate reductase has equal specificity for NADH and NADPH, however in Thermotoga maritimathere it has a greater affinity for NADPH []. In addition, the enzyme is inhibited by high concentrations of its substrate, which consequently acts as a feedback control on the lysine biosynthesis pathway. In T. maritima, the enzyme also lacks N-terminal and C-terminal loops which are present in enzyme of the former two organisms. Short Name:  DapB_C
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0 Child Features

1 Contains

DB identifier Type Name
IPR022664 Conserved_site Dihydrodipicolinate reductase, conserved site

1 Cross References

Identifier
PF05173

1 Found In

DB identifier Type Name
IPR011859 Family Dihydrodipicolinate reductase, plant-type

3 GO Annotations

GO Term Gene Name
GO:0008839 IPR022663
GO:0009089 IPR022663
GO:0055114 IPR022663

3 Ontology Annotations

GO Term Gene Name
GO:0008839 IPR022663
GO:0009089 IPR022663
GO:0055114 IPR022663

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
168311 D8R6G2 PAC:15421275 Selaginella moellendorffii 288  
75294 D8QN51 PAC:15411418 Selaginella moellendorffii 313  
evm.model.supercontig_107.8 PAC:16405387 Carica papaya 155  
evm.model.supercontig_182.24 PAC:16411575 Carica papaya 386  
30147.m014305 B9R9G4 PAC:16820316 Ricinus communis 300  
28266.m000195 B9T529 PAC:16800458 Ricinus communis 354  
Cucsa.007160.1 PAC:16951205 Cucumis sativus 362  
Cucsa.250960.3 PAC:16971731 Cucumis sativus 287  
Cucsa.250960.4 PAC:16971732 Cucumis sativus 240  
Cucsa.250960.1 PAC:16971729 Cucumis sativus 300  
Cucsa.250960.2 PAC:16971730 Cucumis sativus 292  
orange1.1g044326m A0A067D4W0 PAC:18094738 Citrus sinensis 102  
orange1.1g024671m A0A067D771 PAC:18134868 Citrus sinensis 264  
orange1.1g028115m A0A067DFH4 PAC:18134869 Citrus sinensis 213  
orange1.1g022250m A0A067F9D6 PAC:18101158 Citrus sinensis 300  
orange1.1g022057m A0A067EY71 PAC:18101157 Citrus sinensis 303  
orange1.1g027747m A0A067EYA5 PAC:18101161 Citrus sinensis 219  
AT5G52100.1 Q9FJ82 PAC:19670377 Arabidopsis thaliana 298  
AT3G59890.1 Q8LB01 PAC:19663782 Arabidopsis thaliana 349  
AT3G59890.2 Q8LB01 PAC:19663783 Arabidopsis thaliana 343  
AT2G44040.1 O80574 PAC:19642463 Arabidopsis thaliana 347  
Thhalv10006083m V4L1E9 PAC:20190629 Eutrema salsugineum 338  
Thhalv10001534m V4KMD1 PAC:20188868 Eutrema salsugineum 341  
Ciclev10020914m V4TPC8 PAC:20810644 Citrus clementina 349  
Ciclev10005510m V4S434 PAC:20791224 Citrus clementina 303  
Lus10041701 PAC:23146716 Linum usitatissimum 337  
Lus10024047 PAC:23141437 Linum usitatissimum 321  
Lus10027421 PAC:23144450 Linum usitatissimum 280  
Lus10005771 PAC:23169842 Linum usitatissimum 306  
Potri.015G135400.5 PAC:27017621 Populus trichocarpa 272  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7893645
            8873595
            9398235
            18250105