Protein Domain : IPR013149

Type:  Domain Name:  Alcohol dehydrogenase, C-terminal
Description:  Alcohol dehydrogenase () (ADH) catalyzes the reversible oxidation of alcohols to their corresponding acetaldehyde or ketone with the concomitant reduction of NAD:alcohol + NAD = aldehyde or ketone + NADH Currently three structurally and catalytically different types of alcohol dehydrogenases are known:Zinc-containing 'long-chain' alcohol dehydrogenases.Insect-type, or 'short-chain' alcohol dehydrogenases.Iron-containing alcohol dehydrogenases.Zinc-containing ADH's [, ] are dimeric or tetrameric enzymes that bind two atoms of zinc per subunit. One of the zinc atom is essential for catalyticactivity while the other is not. Both zinc atoms are coordinated by either cysteine or histidine residues; the catalytic zinc is coordinated by twocysteines and one histidine. Zinc-containing ADH's are found in bacteria, mammals, plants, and in fungi. In many species there is more than one isozyme(for example, humans have at least six isozymes, yeast have three, etc.). A number of other zinc-dependent dehydrogenases are closely related to zincADH [] and are included in this family.Sorbitol dehydrogenase ()L-threonine 3-dehydrogenase ()Glutathione-dependent formaldehyde dehydrogenase ()Mannitol dehydrogenase ()In addition, this family includes NADP-dependent quinone oxidoreductase (), an enzyme found in bacteria (gene qor), in yeast and in mammals where, in somespecies such as rodents, it has been recruited as an eye lens protein and is known as zeta-crystallin []. The sequence of quinone oxidoreductase isdistantly related to that other zinc-containing alcohol dehydrogenases and it lacks the zinc-ligand residues. The torpedo fish and mammalian synaptic vesiclemembrane protein vat-1 is related to qor.This entry represents the cofactor-binding domain of these enzymes, which is normally found towards the C terminus. Structural studies indicate that it forms a classical Rossman fold that reversibly binds NAD(H) [, , ]. Short Name:  ADH_C
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0 Child Features

1 Contains

DB identifier Type Name
IPR002364 Conserved_site Quinone oxidoreductase/zeta-crystallin, conserved site

1 Cross References

Identifier
PF00107

12 Found Ins

DB identifier Type Name
IPR014187 Family Alcohol dehydrogenase, zinc-binding type 2
IPR020843 Domain Polyketide synthase, enoylreductase domain
IPR014189 Family Quinone oxidoreductase PIG3
IPR014183 Family Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase
IPR014182 Family Alcohol dehydrogenase, zinc-binding type 1
IPR004627 Family L-threonine 3-dehydrogenase
IPR014184 Family Formaldehyde dehydrogenase, glutathione-independent
IPR014188 Family Acrylyl-CoA reductase AcuI
IPR014190 Family Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
IPR017614 Family 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
IPR017743 Family Alcohol dehydrogenase, phosphonate catabolism-associated, putative
IPR017816 Family S-(hydroxymethyl)mycothiol dehydrogenase

1 GO Annotation

GO Term Gene Name
GO:0055114 IPR013149

1 Ontology Annotations

GO Term Gene Name
GO:0055114 IPR013149

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231782 D8RK93 PAC:15419163 Selaginella moellendorffii 344  
412432 D8RLH1 PAC:15411552 Selaginella moellendorffii 390  
97115 D8RMY3 PAC:15408261 Selaginella moellendorffii 140  
432164 D8TF64 PAC:15401298 Selaginella moellendorffii 297  
438334 D8QW74 PAC:15420365 Selaginella moellendorffii 376  
149351 D8RS04 PAC:15410014 Selaginella moellendorffii 351  
149322 D8RRY0 PAC:15409927 Selaginella moellendorffii 380  
267688 D8RS05 PAC:15412886 Selaginella moellendorffii 351  
101142 D8RT24 PAC:15423130 Selaginella moellendorffii 389  
232268 D8RT18 PAC:15418214 Selaginella moellendorffii 377  
102919 D8RVY3 PAC:15409896 Selaginella moellendorffii 197  
267842 D8RVY7 PAC:15414393 Selaginella moellendorffii 376  
230239 D8QX16 PAC:15412317 Selaginella moellendorffii 349  
270370 D8QWD9 PAC:15419604 Selaginella moellendorffii 338  
405152 D8QWE0 PAC:15410878 Selaginella moellendorffii 620  
438497 D8QYJ4 PAC:15421172 Selaginella moellendorffii 426  
107855 D8S344 PAC:15401491 Selaginella moellendorffii 322  
109935 D8S6X2 PAC:15407964 Selaginella moellendorffii 381  
153092 D8S6G9 PAC:15419777 Selaginella moellendorffii 352  
444096 D8S6F1 PAC:15413795 Selaginella moellendorffii 357  
110768 D8S843 PAC:15409827 Selaginella moellendorffii 322  
268499 D8SES2 PAC:15414371 Selaginella moellendorffii 332  
421941 D8SGU9 PAC:15419632 Selaginella moellendorffii 301  
268735 D8SJJ0 PAC:15416417 Selaginella moellendorffii 351  
266960 D8R4H1 PAC:15412208 Selaginella moellendorffii 418  
168073 D8R5J7 PAC:15419226 Selaginella moellendorffii 631  
271876 D8SU49 PAC:15403902 Selaginella moellendorffii 358  
236309 D8T7E6 PAC:15408095 Selaginella moellendorffii 288  
145705 D8RBV6 PAC:15423477 Selaginella moellendorffii 389  
89583 D8RBW7 PAC:15410267 Selaginella moellendorffii 370  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3622514
            8486156
            8504864
            1593644
            12962626
            12627956
            7602590