Protein Domain : IPR011004

Type:  Domain Name:  Trimeric LpxA-like
Description:  This domain is characterised by trimeric LpxA-like enzymes that display a single-stranded left-handed beta-helix fold, composed of tandem repeats of a hexapeptide, as represented by the Bacterial transferase hexapeptide repeat, where the hexapeptide repeats correspond to individual strands. Many bacterial transferases contain this domain. The structures of several proteins with this domain have been determined, including UDP N-acetylglucosamine acyltransferase (LpxA, ) from Escherichia coli, the first enzyme in the lipid A biosynthetic pathway []; galactoside acetyltransferase (GAT, LacA, ) from E. coli, a gene product of the lac operon that may assist cellular detoxification []; gamma-class Archaeon carbonic anhydrase (), a zinc-containing enzyme that catalyses the reversible hydration of carbon dioxide []; tetrahydrodipicolinate-N-succinlytransferase (DapD) from Mycobacterium bovis, an enzyme from the lysine biosynthetic pathway that contains an extra N-terminal 3-helical domain []; and the C-terminal domain of N-acetylglucosamine 1-phosphate uridyltransferase (GlmU, ) from E. coli, a trimeric bifunctional enzyme that catalyses the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine, an essential precursor for many biomolecules []. Short Name:  Trimer_LpxA-like
Paste the following link

0 Child Features

3 Contains

DB identifier Type Name
IPR001451 Repeat Hexapeptide repeat
IPR010493 Domain Serine acetyltransferase, N-terminal
IPR018357 Conserved_site Hexapeptide transferase, conserved site

1 Cross References

Identifier
SSF51161

15 Found Ins

DB identifier Type Name
IPR011831 Family Glucose-1-phosphate adenylyltransferase
IPR005881 Family Serine O-acetyltransferase
IPR005664 Family Tetrahydrodipicolinate N-succinyltransferase, transferase hexapeptide repeat family
IPR007691 Family UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD
IPR010137 Family Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
IPR005882 Family Bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase
IPR017694 Family Phosphonate metabolim protein, transferase hexapeptide repeat family
IPR019873 Family 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase, DapH
IPR019875 Family 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, actinobacteria
IPR019876 Family 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, gammaproteobacteria
IPR012728 Domain Non-ribosomal peptide synthetase C-terminal
IPR017156 Family Carbon dioxide concentrating mechanism protein, CcmM
IPR011832 Family Glucose-1-phosphate adenylyltransferase, GlgD subunit
IPR005908 Family Glucose-1-phosphate thymidylyltransferase, long form
IPR011974 Family Phenylacetic acid degradation protein PaaY

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410953 D8RHJ0 PAC:15409527 Selaginella moellendorffii 2385  
97222 D8RMS4 PAC:15409116 Selaginella moellendorffii 269  
404190 D8QUJ6 PAC:15407894 Selaginella moellendorffii 207  
149205 D8RRG9 PAC:15409108 Selaginella moellendorffii 533  
101485 D8RTV0 PAC:15403220 Selaginella moellendorffii 282  
80047 D8QXL0 PAC:15402284 Selaginella moellendorffii 260  
138695 D8TFY1 PAC:15402256 Selaginella moellendorffii 447  
108866 D8S4R0 PAC:15404354 Selaginella moellendorffii 2439  
233627 D8SC83 PAC:15401735 Selaginella moellendorffii 449  
115472 D8SER8 PAC:15422035 Selaginella moellendorffii 457  
447658 D8T1B0 PAC:15404535 Selaginella moellendorffii 222  
169778 D8RB04 PAC:15405111 Selaginella moellendorffii 463  
71425 D8QQ71 PAC:15423285 Selaginella moellendorffii 206  
90530 D8RD44 PAC:15413359 Selaginella moellendorffii 302  
145865 D8RCC3 PAC:15402142 Selaginella moellendorffii 266  
evm.TU.contig_45133.1 PAC:16432139 Carica papaya 92  
evm.model.supercontig_1000.1 PAC:16404750 Carica papaya 829  
evm.model.supercontig_117.30 PAC:16406386 Carica papaya 459  
evm.model.supercontig_12.177 PAC:16406722 Carica papaya 248  
evm.model.supercontig_123.48 PAC:16407148 Carica papaya 201  
evm.model.supercontig_13.93 PAC:16407904 Carica papaya 245  
evm.model.supercontig_136.75 PAC:16408369 Carica papaya 523  
evm.model.supercontig_139.7 PAC:16408571 Carica papaya 1091  
evm.model.supercontig_147.24 PAC:16409198 Carica papaya 524  
evm.model.supercontig_15.122 PAC:16409336 Carica papaya 99  
evm.model.supercontig_27.251 PAC:16415636 Carica papaya 307  
evm.model.supercontig_55.185 PAC:16422578 Carica papaya 354  
evm.model.supercontig_57.53 PAC:16422876 Carica papaya 559  
evm.model.supercontig_6.143 PAC:16423313 Carica papaya 180  
evm.model.supercontig_62.172 PAC:16423975 Carica papaya 529  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7481807
            11937062
            10924115
            11910040
            11329257