| Type: | Family | Name: | Glucose-1-phosphate thymidylyltransferase, long form |
| Description: | Synonym: dTDP-D-glucose synthase This group of proteins comprises a tightly conserved but broadly distributed subfamily of known and putative bacterial glucose-1-phosphate thymidylyltransferases (). It is well characterised in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose The family of known and putative glucose-1-phosphate thymidyltransferases shows a deep split into a short form (see ) and a long form described by this entry. The homotetrameric short form is found in numerous bacterial species that incorporate dTDP-L-rhamnose, which it helps synthesize, into the cell wall. It is subject to feedback inhibition. The long form, in contrast, is found in many species for which it serves as a sugar-activating enzyme for antibiotic biosynthesis and or other, unknownpathways, and in which dTDP-L-rhamnose is not necessarily produced. | Short Name: | G1P_thy_trans_l |
