Protein Domain : IPR013078

Type:  Family Name:  Histidine phosphatase superfamily, clade-1
Description:  The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylatedduring the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substratebefore, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute differentadditional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of acatalytically essential acidic residue. The superfamily may be divided into two main branches. The relationship between the two branches isnot evident by (PSI-)BLAST but is clear from more sensitive sequence searches and structural comparisons [].The larger clade-1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctionalprotein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutaseactivity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is alsoin clade-1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of smallmolecules in clade-1 members. Short Name:  His_Pase_superF_clade-1
Paste the following link

12 Child Features

DB identifier Type Name
IPR005952 Family Phosphoglycerate mutase 1
IPR003094 Family Fructose-2,6-bisphosphatase
IPR012398 Family PRIB5
IPR017070 Family Uncharacterised conserved protein UCP036920, phosphoglycerate mutase, plant X4/Y4
IPR015845 Family Agropine synthesis reductase
IPR004449 Family Phosphohistidine phosphatase SixA
IPR014636 Family RNase H, phosphoglycerate mutase domain-containing
IPR014623 Family Transcription factor TFIIIC subunit Tfc7/tau55
IPR022492 Family Phosphomutase MSMEG4193, putative
IPR017578 Family Alpha-ribazole phosphatase, CobC
IPR011310 Family Lipopolysaccharide core heptose(II)-phosphate phosphatase
IPR023086 Family Phosphoglycerate mutase, GpmB, probable

0 Contains

2 Cross Referencess

Identifier
PF00300
SM00855

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR029033 Family Histidine phosphatase superfamily

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231879 D8RLS8 PAC:15419889 Selaginella moellendorffii 247  
148597 D8RNA9 PAC:15408650 Selaginella moellendorffii 351  
441792 D8RMK9 PAC:15410330 Selaginella moellendorffii 327  
404222 PAC:15408544 Selaginella moellendorffii 218  
404220 PAC:15408542 Selaginella moellendorffii 218  
404227 D8QUN8 PAC:15408551 Selaginella moellendorffii 293  
404225 D8QUN6 PAC:15408548 Selaginella moellendorffii 218  
413915 D8RR14 PAC:15418228 Selaginella moellendorffii 173  
102624 D8RUY3 PAC:15407499 Selaginella moellendorffii 196  
57148 D8RVF4 PAC:15401951 Selaginella moellendorffii 176  
415701 D8RWY9 PAC:15422419 Selaginella moellendorffii 198  
68511 D8QXV6 PAC:15415097 Selaginella moellendorffii 170  
105019 D8RZ41 PAC:15411828 Selaginella moellendorffii 426  
110087 D8S6R5 PAC:15404405 Selaginella moellendorffii 289  
118991 D8SKB7 PAC:15412542 Selaginella moellendorffii 186  
439299 D8R3F0 PAC:15422628 Selaginella moellendorffii 248  
120962 D8SND7 PAC:15418554 Selaginella moellendorffii 188  
121295 D8SNQ5 PAC:15416214 Selaginella moellendorffii 219  
85568 D8R514 PAC:15420792 Selaginella moellendorffii 221  
229451 D8T1E4 PAC:15410695 Selaginella moellendorffii 268  
427678 D8T0D2 PAC:15412645 Selaginella moellendorffii 200  
402664 D8QMM9 PAC:15405847 Selaginella moellendorffii 248  
73590 D8QMM1 PAC:15407708 Selaginella moellendorffii 315  
89377 D8RBH8 PAC:15408597 Selaginella moellendorffii 270  
63565 D8QP40 PAC:15422784 Selaginella moellendorffii 433  
66964 D8RCT2 PAC:15412420 Selaginella moellendorffii 239  
132820 D8T623 PAC:15408336 Selaginella moellendorffii 495  
evm.model.supercontig_101.38 PAC:16404795 Carica papaya 271  
evm.model.supercontig_124.48 PAC:16407206 Carica papaya 289  
evm.model.supercontig_177.2 PAC:16411117 Carica papaya 243  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18092946