Protein Domain : IPR004360

Type:  Domain Name:  Glyoxalase/fosfomycin resistance/dioxygenase domain
Description:  Glyoxalase I () (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by glyoxalase II to lactic acid [].Glyoxalase I is an ubiquitous enzyme which binds one mole of zinc per subunit. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric. The sequence of glyoxalase I is well conserved.The domain represented by this entry is found in glyoxalase I and in other related proteins, including fosfomycin resistance proteins FosB [], FosA [], FosX [] and dioxygenases (eg. 4-hydroxyphenylpyruvate dioxygenase). Short Name:  Glyas_Fos-R_dOase_dom
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0 Child Features

2 Contains

DB identifier Type Name
IPR018146 Conserved_site Glyoxalase I, conserved site
IPR000486 Conserved_site Extradiol ring-cleavage dioxygenase, class I /II

1 Cross References

Identifier
PF00903

2 Found Ins

DB identifier Type Name
IPR005956 Family 4-hydroxyphenylpyruvate dioxygenase
IPR017515 Family Methylmalonyl-CoA epimerase

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR029068 Domain Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
94230 D8RIL5 PAC:15422662 Selaginella moellendorffii 167  
17835 D8RQD8 PAC:15423006 Selaginella moellendorffii 125  
82216 D8QZI3 PAC:15409610 Selaginella moellendorffii 122  
270490 D8R2P7 PAC:15420430 Selaginella moellendorffii 186  
402441 D8QQN0 PAC:15404225 Selaginella moellendorffii 288  
evm.model.supercontig_28.129 PAC:16415870 Carica papaya 211  
evm.model.supercontig_3368.2 PAC:16417809 Carica papaya 292  
evm.model.supercontig_40.25 PAC:16419425 Carica papaya 362  
evm.model.supercontig_50.111 PAC:16421568 Carica papaya 440  
evm.model.supercontig_65.38 PAC:16424446 Carica papaya 185  
29794.m003421 B9RS22 PAC:16808780 Ricinus communis 389  
29842.m003581 B9RXK1 PAC:16810714 Ricinus communis 280  
29912.m005471 B9RKL0 PAC:16813347 Ricinus communis 369  
29993.m001037 B9S300 PAC:16815321 Ricinus communis 441  
28320.m001105 B9SEP7 PAC:16800556 Ricinus communis 193  
29589.m001237 B9SCI1 PAC:16803278 Ricinus communis 234  
Cucsa.045170.7 A0A0A0KJW2 PAC:16953325 Cucumis sativus 292  
Cucsa.045170.1 A0A0A0KJW2 PAC:16953319 Cucumis sativus 292  
Cucsa.045170.4 A0A0A0KJW2 PAC:16953322 Cucumis sativus 292  
Cucsa.045170.6 A0A0A0KJW2 PAC:16953324 Cucumis sativus 292  
Cucsa.085760.1 PAC:16956692 Cucumis sativus 312  
Cucsa.085760.2 PAC:16956693 Cucumis sativus 294  
Cucsa.085760.3 PAC:16956694 Cucumis sativus 221  
Cucsa.085760.4 PAC:16956695 Cucumis sativus 207  
Cucsa.105320.2 PAC:16959321 Cucumis sativus 118  
Cucsa.116500.1 PAC:16960576 Cucumis sativus 362  
Cucsa.155400.2 PAC:16964769 Cucumis sativus 206  
Cucsa.155400.1 PAC:16964768 Cucumis sativus 206  
Cucsa.058800.1 A0A0A0KZ39 PAC:16954726 Cucumis sativus 455  
Cucsa.058800.2 A0A0A0KZ39 PAC:16954727 Cucumis sativus 455  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7684374
            17567049
            11244082
            15741169