Protein Domain : IPR000486

Type:  Conserved_site Name:  Extradiol ring-cleavage dioxygenase, class I /II
Description:  Dioxygenases catalyse the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms. Cleavage of aromatic rings is one of the most important functions of dioxygenases, which play key roles in the degradation of aromatic compounds. The substrates of ring-cleavage dioxygenases can be classified into two groups according to the mode of scission of the aromatic ring. Intradiol enzymes () use a non-haem Fe(III) to cleave the aromatic ring between two hydroxyl groups (ortho-cleavage), whereas extradiol enzymes use a non-haem Fe(II) to cleave the aromatic ring between a hydroxylated carbon and an adjacent non-hydroxylated carbon (meta-cleavage) [, ]. These two subfamilies differ in sequence, structural fold, iron ligands, and the orientation of second sphere active site amino acid residues. Extradiol dioxygenases are usually homo-multimeric, bind one atom of ferrous ion per subunit and have a subunit size of about 33 kDa. Extradiol dioxygenases can be divided into three classes. Class I and II enzymes show sequence similarity, with the two-domain class II enzymes having evolved from a class I enzyme through gene duplication. As a result, the class II enzymes are composed of two domains with approximately the same folding pattern as each other. Class III enzymes (, ) are different in sequence and structure, but they do share several common active-site characteristics with the class II enzymes, in particular the coordination sphere and the disposition of the putative catalytic base are very similar. This entry represents the dioxygenase domain found in class I and class II extradiol enzymes.Enzymes that belong to the extradiol class II family include catechol 2,3-dioxygenase (2,3-CTD) () and biphenyl-2,3-diol 1,2-dioxygenase (BphC) (). Short Name:  Xdiol_ring_cleave_dOase_1/2
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00082

3 Found Ins

DB identifier Type Name
IPR004360 Domain Glyoxalase/fosfomycin resistance/dioxygenase domain
IPR017626 Family 2,3-dihydroxybiphenyl 1,2-dioxygenase
IPR017624 Family Catechol 2,3 dioxygenase

4 GO Annotations

GO Term Gene Name
GO:0003824 IPR000486
GO:0008198 IPR000486
GO:0006725 IPR000486
GO:0055114 IPR000486

4 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR000486
GO:0008198 IPR000486
GO:0006725 IPR000486
GO:0055114 IPR000486

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15264822
            10730195