Protein Domain : IPR004088

Type:  Domain Name:  K Homology domain, type 1
Description:  The K homology (KH) domain was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. It is a domain of around 70 amino acidsthat is present in a wide variety of quite diverse nucleic acid-binding proteins []. It has been shown to bind RNA [, ]. Like many other RNA-binding motifs, KH motifs are found in one or multiple copies (14 copies in chicken vigilin) and, at least for hnRNP K (three copies) and FMR-1 (two copies), each motif is necessary for in vitroRNA binding activity, suggesting that they may function cooperatively or, in the case of single KH motif proteins (for example, Mer1p), independently [].According to structural [, , ] analysis the KH domain can be separated in two groups. The first group or type-1 contain a beta-alpha-alpha-beta-beta-alpha structure, whereas in the type-2 the two last beta-sheet are located in the N-terminal part of the domain (alpha-beta-beta-alpha-alpha-beta). Sequence similarity between these two folds are limited to a short region (VIGXXGXXI) in the RNA binding motif. This motif is located between helice 1 and 2 in type-1 and between helice 2 and 3 in type-2. Proteins known to contain a type-1 KH domain include bacterial polyribonucleotide nucleotidyltransferases (); vertebrate fragile X mental retardation protein 1 (FMR1); eukaryotic heterogeneous nuclear ribonucleoprotein K (hnRNP K), one of at least 20 major proteins that are part of hnRNP particles in mammalian cells; mammalian poly(rC) binding proteins; Artemia salinaglycine-rich protein GRP33; yeast PAB1-binding protein 2 (PBP2); vertebrate vigilin; and human high-density lipoprotein binding protein (HDL-binding protein). Short Name:  KH_dom_type_1
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0 Child Features

0 Contains

5 Cross Referencess

Identifier
PF00013
PF13014
PS50084
G3DSA:3.30.1370.10
SSF54791

8 Found Ins

DB identifier Type Name
IPR012162 Family Polyribonucleotide nucleotidyltransferase
IPR010213 Domain Transcription termination factor NusA
IPR009210 Family Activating signal cointegrator 1 complex subunit 1
IPR017705 Family Ribonuclease Y
IPR019964 Family KH domain protein, archaea
IPR010212 Family Probable transcription termination protein NusA, archaeal
IPR020627 Family Uncharacterised protein family UPF0109
IPR014069 Family Guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase

1 GO Annotation

GO Term Gene Name
GO:0003723 IPR004088

1 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR004088

1 Parent Features

DB identifier Type Name
IPR004087 Domain K Homology domain

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
430894 D8TAV6 PAC:15423157 Selaginella moellendorffii 982  
100146 D8RS18 PAC:15420322 Selaginella moellendorffii 260  
141745 D8QYF0 PAC:15411981 Selaginella moellendorffii 231  
104837 D8RZE6 PAC:15415070 Selaginella moellendorffii 328  
107582 D8S393 PAC:15421480 Selaginella moellendorffii 347  
107444 D8S326 PAC:15420732 Selaginella moellendorffii 247  
178562 D8SC78 PAC:15407796 Selaginella moellendorffii 539  
227548 D8R0X3 PAC:15405495 Selaginella moellendorffii 215  
445107 D8SFP6 PAC:15417185 Selaginella moellendorffii 802  
445677 D8SKD7 PAC:15421100 Selaginella moellendorffii 668  
445667 D8SKA3 PAC:15421075 Selaginella moellendorffii 1020  
84338 D8R4B3 PAC:15416288 Selaginella moellendorffii 271  
84724 D8R2V3 PAC:15419311 Selaginella moellendorffii 705  
85231 D8R6S7 PAC:15418432 Selaginella moellendorffii 324  
402098 D8QPK6 PAC:15401348 Selaginella moellendorffii 224  
77425 D8QTG9 PAC:15418598 Selaginella moellendorffii 808  
73985 D8QQD9 PAC:15410910 Selaginella moellendorffii 502  
75886 D8QND8 PAC:15415990 Selaginella moellendorffii 213  
73732 D8QN19 PAC:15409211 Selaginella moellendorffii 125  
77639 D8QRH9 PAC:15420148 Selaginella moellendorffii 125  
437890 D8QRQ4 PAC:15421287 Selaginella moellendorffii 471  
88821 D8R9L2 PAC:15409444 Selaginella moellendorffii 272  
409630 D8RDI2 PAC:15403861 Selaginella moellendorffii 393  
90688 D8RCT1 PAC:15414269 Selaginella moellendorffii 146  
evm.TU.contig_30793.3 PAC:16429889 Carica papaya 271  
evm.TU.contig_31439.1 PAC:16429981 Carica papaya 410  
evm.TU.contig_33990.1 PAC:16430370 Carica papaya 641  
evm.TU.contig_34690.1 PAC:16430496 Carica papaya 95  
evm.TU.contig_35560.1 PAC:16430670 Carica papaya 139  
evm.TU.contig_44017.1 PAC:16431950 Carica papaya 120  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8036511
            9302998
            10369774
            11160884