Protein Domain : IPR029063

Type:  Domain Name:  S-adenosyl-L-methionine-dependent methyltransferase
Description:  This entry represents a domain found in S-adenosyl-L-methionine-dependent methyltransferases (SAM MTases). Proteins containing this domain include members from the methyltransferase superfamily and the class I-like SAM-binding methyltransferase superfamily. Methyltransferases transfer a methyl group from a donor to an acceptor. SAM-binding methyltransferases utilise the ubiquitous methyl donor SAM as a cofactor to methylate proteins, small molecules, lipids, and nucleic acids. All SAM MTases contain a structurally conserved SAM-binding domain consisting of a central seven-stranded beta-sheet that is flanked by three alpha-helices per side of the sheet []. A review published in 2003 [] divides all methyltransferases into 5 classes based on the structure of their catalytic domain (fold):class I: Rossmann-like alpha/betaclass II: TIM beta/alpha-barrel alpha/betaclass III: tetrapyrrole methylase alpha/betaclass IV: SPOUT alpha/beta class V: SET domain all beta Another paper [] based on a study of the Saccharomyces cerevisiae methyltransferome argues for four more folds:class VI: transmembrane all alpha class VII: DNA/RNA-binding 3-helical bundle all alphaclass VIII: SSo0622-like alpha+betaclass IX: thymidylate synthetase alpha+betaThe vast majority of methyltransferases belong to the Rossmann-like fold (Class I) which consists in a seven-stranded beta sheet adjoined by alpha helices. The beta sheet contains a central topological switch-point resulting in a deep cleft in which SAM binds. Class I methyltransferases display two conserved positions, the first one is a GxGxG motif (or at least a GxG motif) at the end of the first beta strand which is characteristic of a nucleotide-binding site and is hence used to bind the adenosyl part of SAM, the second conserved position is an acidic residue at the end of the second beta strand that forms one hydrogen bond to each hydroxyl of the SAM ribose part. The core of these enzymes is composed by about 150 amino acids that show very strong spatial conservation []. Short Name:  SAM-dependent_MTases
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17 Child Features

DB identifier Type Name
IPR013216 Domain Methyltransferase type 11
IPR013110 Domain Histone methylation DOT1
IPR001678 Domain SAM-dependent methyltransferase RsmB/NOP2-type
IPR030374 Domain Polyamine biosynthesis domain
IPR001077 Domain O-methyltransferase, family 2
IPR030380 Domain SAM-dependent methyltransferase DRM
IPR030382 Domain SAM-dependent methyltransferase TRM5/TYW2-type
IPR030384 Domain SAM-dependent methyltransferase SMT-type
IPR025714 Domain Methyltransferase domain
IPR002877 Domain Ribosomal RNA methyltransferase FtsJ domain
IPR006342 Domain Methyltransferase FkbM
IPR004971 Domain mRNA (guanine-N(7))-methyltransferase domain
IPR007848 Domain Methyltransferase small domain
IPR022642 Domain MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal
IPR025789 Domain Histone-lysine N-methyltransferase DOT1 domain
IPR015985 Domain Tellurite resistance methyltransferase TehB-like domain
IPR003356 Domain DNA methylase, adenine-specific

0 Contains

2 Cross Referencess

Identifier
G3DSA:3.40.50.150
SSF53335

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

113993 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
170913 D8RF10 PAC:15409761 Selaginella moellendorffii 603  
146890 D8RG72 PAC:15405060 Selaginella moellendorffii 232  
171051 D8RFP8 PAC:15405843 Selaginella moellendorffii 296  
410601 D8RF92 PAC:15407009 Selaginella moellendorffii 214  
410587 D8RF77 PAC:15406490 Selaginella moellendorffii 652  
92673 D8RFN8 PAC:15419997 Selaginella moellendorffii 230  
134942 D8T9B3 PAC:15415114 Selaginella moellendorffii 277  
430483 D8T9K0 PAC:15420171 Selaginella moellendorffii 216  
47053 D8T9M6 PAC:15416332 Selaginella moellendorffii 243  
430530 D8T9P5 PAC:15420813 Selaginella moellendorffii 212  
135385 D8TA78 PAC:15413551 Selaginella moellendorffii 401  
430728 D8TAB7 PAC:15422222 Selaginella moellendorffii 655  
147057 D8RGQ2 PAC:15401857 Selaginella moellendorffii 215  
448841 D8TAK6 PAC:15409052 Selaginella moellendorffii 446  
411052 D8RGF7 PAC:15405510 Selaginella moellendorffii 459  
411012 D8RHQ6 PAC:15405415 Selaginella moellendorffii 399  
411110 D8RGL7 PAC:15406196 Selaginella moellendorffii 565  
411241 D8RH09 PAC:15406981 Selaginella moellendorffii 347  
441112 D8RGL9 PAC:15405451 Selaginella moellendorffii 311  
93468 D8RGT4 PAC:15421283 Selaginella moellendorffii 478  
93209 D8RHJ1 PAC:15419735 Selaginella moellendorffii 534  
93162 D8RGG1 PAC:15419133 Selaginella moellendorffii 177  
93906 D8RGY8 PAC:15402666 Selaginella moellendorffii 311  
93775 D8RHA6 PAC:15401324 Selaginella moellendorffii 308  
93926 D8RH06 PAC:15402706 Selaginella moellendorffii 287  
136061 D8TBC3 PAC:15414181 Selaginella moellendorffii 179  
411670 D8RIN4 PAC:15410250 Selaginella moellendorffii 210  
136794 D8TCC6 PAC:15419494 Selaginella moellendorffii 476  
94369 D8RHX8 PAC:15423442 Selaginella moellendorffii 267  
94356 D8RIN3 PAC:15423411 Selaginella moellendorffii 359  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12826405
            21858014
            12504684