Protein Domain : IPR013216

Type:  Domain Name:  Methyltransferase type 11
Description:  Methyl transfer from the ubiquitous S-adenosyl-L-methionine (SAM) to either nitrogen, oxygen or carbon atoms is frequently employed in diverse organisms ranging from bacteria to plants and mammals. The reaction is catalyzed by methyltransferases (Mtases) and modifies DNA, RNA, proteins and small molecules, such as catechol for regulatory purposes. The various aspects of the role of DNA methylation in prokaryotic restriction-modification systems and in a number of cellular processes in eukaryotes including gene regulation and differentiation is well documented.This entry represents a methyltransferase domain found in a large variety of SAM-dependent methyltransferases including, but not limited to: Arsenite methyltransferase () which converts arsenical compounds to their methylated forms []Biotin synthesis protein bioC, which is involved in the early stages of biotin biosyntheis []Arginine N-methyltransferase 1, an arginine-methylating enzyme which acts on residues present in a glycine and argine-rich domain and can methylate histones []Hexaprenyldihydroxybenzoate methyltransferase (), a mitochodrial enzyme involved in ubiquinone biosynthesis []A probable cobalt-precorrin-6Y C(15)-methyltransferase thought to be involved in adenosylcobalamin biosynthesis []Sterol 24-C-methyltransferase (), shown to participate in ergosterol biosynthesis []3-demethylubiquinone-9 3-methyltransferase () involved in ubiquinone biosynthesis []Structural studies show that this domain forms the Rossman-like alpha-beta fold typical of SAM-dependent methyltransferases [, , ]. Short Name:  Methyltransf_11
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1 Child Features

DB identifier Type Name
IPR031164 Domain SAM-binding methyltransferase MPBQ/MBSQ

0 Contains

1 Cross References

Identifier
PF08241

6 Found Ins

DB identifier Type Name
IPR010233 Family Ubiquinone biosynthesis O-methyltransferase
IPR011814 Family Malonyl-[acyl-carrier protein] O-methyltransferase BioC
IPR016718 Family rRNA (guanine-N1-)-methyltransferase A, predicted
IPR020027 Family Pseudaminic acid biosynthesis-associated methyltransferase
IPR016885 Family Uncharacterised conserved protein UCP028445
IPR005271 Family tRNA (cmo5U34)-methyltransferase

2 GO Annotations

GO Term Gene Name
GO:0008168 IPR013216
GO:0008152 IPR013216

2 Ontology Annotations

GO Term Gene Name
GO:0008168 IPR013216
GO:0008152 IPR013216

1 Parent Features

DB identifier Type Name
IPR029063 Domain S-adenosyl-L-methionine-dependent methyltransferase

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
441112 D8RGL9 PAC:15405451 Selaginella moellendorffii 311  
93162 D8RGG1 PAC:15419133 Selaginella moellendorffii 177  
93926 D8RH06 PAC:15402706 Selaginella moellendorffii 287  
136061 D8TBC3 PAC:15414181 Selaginella moellendorffii 179  
94369 D8RHX8 PAC:15423442 Selaginella moellendorffii 267  
95789 D8RKQ4 PAC:15407134 Selaginella moellendorffii 553  
57159 D8RLD8 PAC:15401969 Selaginella moellendorffii 203  
96831 D8RLM8 PAC:15410862 Selaginella moellendorffii 396  
97591 D8RMH9 PAC:15411626 Selaginella moellendorffii 228  
78730 D8QVJ1 PAC:15401476 Selaginella moellendorffii 285  
442094 D8RQ85 PAC:15407756 Selaginella moellendorffii 1754  
99567 PAC:15417382 Selaginella moellendorffii 320  
150376 D8RVQ4 PAC:15413321 Selaginella moellendorffii 291  
228338 D8RWL6 PAC:15406856 Selaginella moellendorffii 351  
230434 D8R0N1 PAC:15413943 Selaginella moellendorffii 276  
445040 D8SF24 PAC:15416470 Selaginella moellendorffii 334  
117268 D8SHM7 PAC:15404049 Selaginella moellendorffii 298  
167817 D8R439 PAC:15422169 Selaginella moellendorffii 287  
424575 D8SQC6 PAC:15403004 Selaginella moellendorffii 359  
86096 D8R669 PAC:15419955 Selaginella moellendorffii 205  
229976 D8QNS7 PAC:15414646 Selaginella moellendorffii 293  
235009 D8SSP1 PAC:15402923 Selaginella moellendorffii 340  
402173 D8QPU1 PAC:15402092 Selaginella moellendorffii 302  
427489 D8SZS5 PAC:15411195 Selaginella moellendorffii 276  
402502 D8QQV3 PAC:15404902 Selaginella moellendorffii 604  
89663 D8RAP5 PAC:15410995 Selaginella moellendorffii 341  
145351 D8RAL6 PAC:15420619 Selaginella moellendorffii 291  
89835 D8RAL9 PAC:15412434 Selaginella moellendorffii 289  
89857 D8RAP8 PAC:15412480 Selaginella moellendorffii 315  
75059 D8QPM9 PAC:15409725 Selaginella moellendorffii 263  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8501034
            12429089
            10419476
            11790780
            9063571
            10848611
            9593144
            1479344
            12737817
            14999102