Protein Domain : IPR016039

Type:  Domain Name:  Thiolase-like
Description:  This entry represents a structural domain with a thiolase-like 3-layer alpha/beta/alpha topology. This domain usually occurs in two similar copies that are related by a pseudo-dyad, and which arose through duplication. The proteins in this entry can be split into two groups: those related to thiolase, and those related to chalcone synthase. The thiolase-like enzymes include:Thiolase, where the topology of each domain is similar to the first domain of phosphoglucomutase []Beta-ketoacyl-ACP synthases types I () and II () [, ]Actinorhodin polyketide beta-ketoacyl synthases 1 and 2 []Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase; ) []The chalcone synthase-like enzymes include:Chalcone synthase () []Ketoacyl-ACP synthase III (FabH; ) []Polyketide synthases []3-hydroxy-3-methylglutaryl CoA synthase () []Dihydropinosylvin synthase [] Short Name:  Thiolase-like
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0 Child Features

16 Contains

DB identifier Type Name
IPR012328 Domain Chalcone/stilbene synthase, C-terminal
IPR013746 Domain Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
IPR013751 Domain 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
IPR014030 Domain Beta-ketoacyl synthase, N-terminal
IPR014031 Domain Beta-ketoacyl synthase, C-terminal
IPR013601 Domain FAE1/Type III polyketide synthase-like protein
IPR013747 Domain 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR001099 Domain Chalcone/stilbene synthase, N-terminal
IPR020617 Domain Thiolase, C-terminal
IPR020616 Domain Thiolase, N-terminal
IPR020610 Active_site Thiolase, active site
IPR020613 Conserved_site Thiolase, conserved site
IPR020615 Active_site Thiolase, acyl-enzyme intermediate active site
IPR018201 Active_site Beta-ketoacyl synthase, active site
IPR000590 Active_site Hydroxymethylglutaryl-coenzyme A synthase, active site
IPR018088 Active_site Chalcone/stilbene synthase, active site

2 Cross Referencess

Identifier
G3DSA:3.40.47.10
SSF53901

6 Found Ins

DB identifier Type Name
IPR010122 Family Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR004655 Family 3-oxoacyl-[acyl-carrier-protein] synthase 3
IPR020841 Domain Polyketide synthase, beta-ketoacyl synthase domain
IPR017568 Family 3-oxoacyl-[acyl-carrier-protein] synthase 2
IPR017236 Family Glycine/sarcosine/betaine reductase, component C, beta
IPR010894 Family Stage V sporulation AD

2 GO Annotations

GO Term Gene Name
GO:0003824 IPR016039
GO:0008152 IPR016039

2 Ontology Annotations

GO Term Gene Name
GO:0003824 IPR016039
GO:0008152 IPR016039

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171238 D8RG92 PAC:15407278 Selaginella moellendorffii 439  
231846 D8RL01 PAC:15419824 Selaginella moellendorffii 266  
149056 D8RQG3 PAC:15407591 Selaginella moellendorffii 508  
100946 D8RTG8 PAC:15404002 Selaginella moellendorffii 433  
141785 D8QWD7 PAC:15412069 Selaginella moellendorffii 462  
405294 D8QWW4 PAC:15411733 Selaginella moellendorffii 112  
405308 D8QWX9 PAC:15412272 Selaginella moellendorffii 539  
79947 D8QXX0 PAC:15405940 Selaginella moellendorffii 534  
268118 D8S3G0 PAC:15411860 Selaginella moellendorffii 486  
443640 D8S354 PAC:15415316 Selaginella moellendorffii 510  
233330 D8S7S2 PAC:15421714 Selaginella moellendorffii 466  
53281 D8S9X4 PAC:15413484 Selaginella moellendorffii 434  
420655 D8SCP6 PAC:15414542 Selaginella moellendorffii 338  
270496 D8R0V0 PAC:15420434 Selaginella moellendorffii 386  
115401 D8SET3 PAC:15421918 Selaginella moellendorffii 554  
179152 D8SES9 PAC:15407617 Selaginella moellendorffii 457  
230708 D8R479 PAC:15416088 Selaginella moellendorffii 411  
423968 D8SND5 PAC:15403120 Selaginella moellendorffii 198  
121372 D8SNR1 PAC:15416930 Selaginella moellendorffii 450  
181394 D8SNT2 PAC:15415565 Selaginella moellendorffii 399  
424337 D8SPK0 PAC:15401438 Selaginella moellendorffii 483  
122361 D8SQD7 PAC:15419808 Selaginella moellendorffii 393  
234869 D8SQX3 PAC:15406284 Selaginella moellendorffii 433  
230794 D8R5U3 PAC:15416271 Selaginella moellendorffii 374  
407420 D8R5J4 PAC:15418951 Selaginella moellendorffii 374  
13435 D8SRF6 PAC:15408302 Selaginella moellendorffii 52  
229853 PAC:15413799 Selaginella moellendorffii 430  
429498 D8T6D5 PAC:15417010 Selaginella moellendorffii 575  
447769 D8T275 PAC:15405358 Selaginella moellendorffii 408  
231054 PAC:15413805 Selaginella moellendorffii 430  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11732902
            11243824
            15292254
            9482715
            9402066
            15286723
            15286722
            15380179
            15229654
            16441657