Protein Domain : IPR002401

Type:  Family Name:  Cytochrome P450, E-class, group I
Description:  Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty acids and xenobiotics, and are important for the detoxification and clearance of various compounds, as well as for hormone synthesis and breakdown, cholesterol synthesis and vitamin D metabolism. In plants, these proteins are important for the biosynthesis of several compounds such as hormones, defensive compounds and fatty acids. In bacteria, they are important for several metabolic processes, such as the biosynthesis of antibiotic erythromycin in Saccharopolyspora erythraea(Streptomyces erythraeus).Cytochrome P450 enzymes use haem to oxidise their substrates, using protons derived from NADH or NADPH to split the oxygen so a single atom can be added to a substrate. They also require electrons, which they receive from a variety of redox partners. In certain cases, cytochrome P450 can be fused to its redox partner to produce a bi-functional protein, such as with P450BM-3 from Bacillus megaterium[], which has haem and flavin domains.Organisms produce many different cytochrome P450 enzymes (at least 58 in humans), which together with alternative splicing can provide a wide array of enzymes with different substrate and tissue specificities. Individual cytochrome P450 proteins follow the nomenclature: CYP, followed by a number (family), then a letter (subfamily), and another number (protein); e.g. CYP3A4 is the fourth protein in family 3, subfamily A. In general, family members should share >40% identity, while subfamily members should share >55% identity.Cytochrome P450 proteins can also be grouped by two different schemes. One scheme was based on a taxonomic split: class I (prokaryotic/mitochondrial) and class II (eukaryotic microsomes). The other scheme was based on the number of components in the system: class B (3-components) and class E (2-components). These classes merge to a certain degree. Most prokaryotes and mitochondria (and fungal CYP55) have 3-component systems (class I/class B) - a FAD-containing flavoprotein (NAD(P)H-dependent reductase), an iron-sulphur protein and P450. Most eukaryotic microsomes have 2-component systems (class II/class E) - NADPH:P450 reductase (FAD and FMN-containing flavoprotein) and P450. There are exceptions to this scheme, such as 1-component systems that resemble class E enzymes [, , ]. The class E enzymes can be further subdivided into five sequence clusters, groups I-V, each of which may contain more than one cytochrome P450 family (eg, CYP1 and CYP2 are both found in group I). The divergence of the cytochrome P450 superfamily into B- and E-classes, and further divergence into stable clusters within the E-class, appears to be very ancient, occurring before the appearance of eukaryotes.This entry represents class E cytochrome P450 proteins that fall into sequence cluster group I. Group I is richest in members, consisting of cytochrome P450 families CYP1, CYP2, CYP17, CYP21 and CYP71. The members of the first four families are of vertebrate origin, while those from CYP71 are derived from plants. CYP1 and CYP2 enzymes mainly metabolise exogenous substrates, whereas CYP17 and CYP21 are involved in metabolism of endogenous physiologically-active compounds. Short Name:  Cyt_P450_E_grp-I
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7 Child Features

DB identifier Type Name
IPR008069 Family Cytochrome P450, E-class, group I, CYP2D-like
IPR008066 Family Cytochrome P450, E-class, group I, CYP1
IPR008067 Family Cytochrome P450, E-class, group I, CYP2A-like
IPR008068 Family Cytochrome P450, E-class, group I, CYP2B-like
IPR008070 Family Cytochrome P450, E-class, group I, CYP2E-like
IPR008071 Family Cytochrome P450, E-class, group I, CYP2J-like
IPR020469 Family Cytochrome P450, CYP2 family

1 Contains

DB identifier Type Name
IPR017972 Conserved_site Cytochrome P450, conserved site

1 Cross References

Identifier
PR00463

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0005506 IPR002401
GO:0016705 IPR002401
GO:0020037 IPR002401
GO:0055114 IPR002401

4 Ontology Annotations

GO Term Gene Name
GO:0005506 IPR002401
GO:0016705 IPR002401
GO:0020037 IPR002401
GO:0055114 IPR002401

1 Parent Features

DB identifier Type Name
IPR001128 Family Cytochrome P450

56997 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231370 D8RF12 PAC:15416106 Selaginella moellendorffii 474  
440934 D8RFH9 PAC:15408706 Selaginella moellendorffii 529  
92387 D8RG39 PAC:15417749 Selaginella moellendorffii 190  
92671 D8RFT7 PAC:15419994 Selaginella moellendorffii 205  
92836 D8RG42 PAC:15421342 Selaginella moellendorffii 515  
430410 D8T9B9 PAC:15419993 Selaginella moellendorffii 452  
430406 D8T9B5 PAC:15419980 Selaginella moellendorffii 444  
5625 D8T9P7 PAC:15420219 Selaginella moellendorffii 91  
22493 D8RGK7 PAC:15412806 Selaginella moellendorffii 477  
93385 D8RGK9 PAC:15420656 Selaginella moellendorffii 503  
93320 D8RHI7 PAC:15420546 Selaginella moellendorffii 150  
93267 D8RGF6 PAC:15419853 Selaginella moellendorffii 158  
93924 D8RGM0 PAC:15402699 Selaginella moellendorffii 300  
171715 D8RIA8 PAC:15411229 Selaginella moellendorffii 511  
147392 D8RIB6 PAC:15404134 Selaginella moellendorffii 510  
411574 D8RID1 PAC:15409440 Selaginella moellendorffii 337  
94261 D8RIC0 PAC:15422716 Selaginella moellendorffii 510  
94002 D8RIC2 PAC:15421036 Selaginella moellendorffii 510  
441298 D8RID2 PAC:15406419 Selaginella moellendorffii 510  
94541 D8RID0 PAC:15402628 Selaginella moellendorffii 508  
431307 D8TC64 PAC:15422022 Selaginella moellendorffii 423  
94367 D8RIC9 PAC:15423440 Selaginella moellendorffii 510  
147479 D8RIR2 PAC:15404862 Selaginella moellendorffii 455  
12239 D8RJU8 PAC:15403795 Selaginella moellendorffii 464  
95630 D8RJX0 PAC:15406332 Selaginella moellendorffii 123  
96541 D8RLS2 PAC:15408479 Selaginella moellendorffii 512  
96503 D8RLS5 PAC:15408385 Selaginella moellendorffii 473  
172829 D8RMX3 PAC:15414952 Selaginella moellendorffii 508  
412962 D8RMX1 PAC:15415484 Selaginella moellendorffii 200  
441830 D8RMX6 PAC:15410970 Selaginella moellendorffii 508  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16042601
            17023115
            15128046
            8637843