Protein Domain : IPR011059

Type:  Domain Name:  Metal-dependent hydrolase, composite domain
Description:  The composite domain of metal-dependent hydrolases has a pseudo-barrel fold that is interrupted by the catalytic beta/alpha barrel domain. This domain is found in a variety of bacterial and fungal enzymes, including: cytosine deaminase, an enzyme that is important in the pyrimidine salvage pathway []; the alpha-subunit of urease, a virulence factor of gastric pathogens such as Helicobacter pylori(Campylobacter pylori) []; D- and L-hydantoinases (dihydropyrimidinase), which catalyse the production of D- and L-amino acids, respectively []; isoaspartyl dipeptidase from Escherichia coli, which functions in protein degradation []; N-acetylglucosamine-6-phosphate deacetylase, which is an enzyme from the biosynthetic pathway to amino-sugar-nucleotides []; and N-acyl-D-amino acid amidohydrolase (D-aminoacylase), involved in the synthesis of D-amino acids []. Short Name:  Metal-dep_hydrolase_composite
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0 Child Features

4 Contains

DB identifier Type Name
IPR017951 Domain Urease, alpha subunit, C-terminal
IPR011612 Domain Urease alpha-subunit, N-terminal domain
IPR002195 Conserved_site Dihydroorotase, conserved site
IPR017950 Active_site Urease active site

2 Cross Referencess

Identifier
G3DSA:2.30.40.10
SSF51338

14 Found Ins

DB identifier Type Name
IPR010229 Family Peptidase M38, beta-aspartyl dipeptidase
IPR011778 Family Hydantoinase/dihydropyrimidinase
IPR005848 Family Urease, alpha subunit
IPR017593 Family Allantoinase
IPR014311 Family Guanine deaminase
IPR003764 Family N-acetylglucosamine-6-phosphate deacetylase
IPR004722 Family Dihydroorotase
IPR005920 Family Imidazolonepropionase
IPR008221 Family Urease
IPR006679 Family Adenine deaminase
IPR010252 Family Formiminoglutamate deiminase
IPR012696 Family Phosphonate metabolism PhnM
IPR017700 Family Putative selenium metabolism protein SsnA
IPR012027 Family Formylmethanofuran dehydrogenase, subunit A

1 GO Annotation

GO Term Gene Name
GO:0016810 IPR011059

1 Ontology Annotations

GO Term Gene Name
GO:0016810 IPR011059

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
431517 D8TCX5 PAC:15401328 Selaginella moellendorffii 468  
431924 D8TEE4 PAC:15404348 Selaginella moellendorffii 136  
432173 D8TF75 PAC:15401327 Selaginella moellendorffii 524  
442187 D8RRF9 PAC:15408541 Selaginella moellendorffii 502  
444093 D8S6E6 PAC:15413792 Selaginella moellendorffii 473  
112083 D8SA01 PAC:15410410 Selaginella moellendorffii 380  
115476 D8SET7 PAC:15422040 Selaginella moellendorffii 390  
83918 D8R305 PAC:15417875 Selaginella moellendorffii 491  
423336 D8SLC3 PAC:15420867 Selaginella moellendorffii 296  
164034 D8QR62 PAC:15407311 Selaginella moellendorffii 564  
402380 D8QQF9 PAC:15403555 Selaginella moellendorffii 969  
408263 PAC:15420400 Selaginella moellendorffii 896  
403755 D8QSF3 PAC:15409570 Selaginella moellendorffii 520  
91337 D8REU5 PAC:15414794 Selaginella moellendorffii 851  
427827 D8T0U4 PAC:15414139 Selaginella moellendorffii 388  
evm.model.supercontig_12.179 PAC:16406724 Carica papaya 81  
evm.model.supercontig_139.21 PAC:16408518 Carica papaya 114  
evm.model.supercontig_184.18 PAC:16411642 Carica papaya 161  
evm.model.supercontig_27.55 PAC:16415676 Carica papaya 501  
evm.model.supercontig_34.179 PAC:16417914 Carica papaya 149  
evm.model.supercontig_34.180 PAC:16417916 Carica papaya 290  
evm.model.supercontig_38.39 PAC:16418874 Carica papaya 157  
evm.model.supercontig_43.29 PAC:16419985 Carica papaya 837  
29851.m002399 B9RZ78 PAC:16811426 Ricinus communis 500  
29868.m000353 B9SXX3 PAC:16811859 Ricinus communis 503  
29929.m004606 B9RMA1 PAC:16813845 Ricinus communis 471  
29929.m004696 B9RMJ1 PAC:16813935 Ricinus communis 842  
30131.m007193 B9RGA4 PAC:16819014 Ricinus communis 574  
30147.m013822 B9RAP8 PAC:16819838 Ricinus communis 650  
30154.m001127 B9S0U2 PAC:16820758 Ricinus communis 405  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11812140
            12127484
            12837777
            12718528
            14557261
            12454005