| Type: | Family | Name: | Hydantoinase/dihydropyrimidinase |
| Description: | Dihydropyrimidinase (DHPase) catalyses the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines []. Primarily converts 5,6-dihydrouracil to N-carbamyl-beta-alanine (also called 3-ureidopropanoate) but also acts on dihydrothymine and hydantoin. The enzyme is a metalloenzyme [].This entry represents the hydantoinase/dihydropyrimidinase family, which also includes D-phenylhydantoinases. This enzyme catalyses the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position, and has no activity on dihydropyrimidines [].Dihydropyrimidinase-related proteins (collapsin response mediator proteins, CRMPs) share sequence similarity with liver DHPase. Although purified CRMP does not hydrolyse DHPase substrates, it is likely that a relatedactivity accounts for its participation in neuronal growth cone signaling []. CRMP3 has histone H4 deacetylase activity []. | Short Name: | Hydantoinase/dihydroPyrase |
| DB identifier | Type | Name |
|---|---|---|
| IPR030615 | Family | Dihydropyrimidinase-related protein 2 |
| IPR030612 | Family | Dihydropyrimidinase-related protein 4 |
| IPR030633 | Family | Dihydropyrimidinase |
| IPR030628 | Family | Dihydropyrimidinase-related protein 3 |
| IPR030626 | Family | Dihydropyrimidinase-related protein 5 |
| IPR030624 | Family | Dihydropyrimidinase-related protein 1 |
| IPR023766 | Family | D-phenylhydantoinase |
