Protein Domain : IPR001789

Type:  Domain Name:  Signal transduction response regulator, receiver domain
Description:  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].Bipartite response regulator proteins are involved in a two-component signal transduction system in bacteria, and certain eukaryotes like protozoa, that functions to detect and respond to environmental changes []. These systems have been detected during host invasion, drug resistance, motility, phosphate uptake, osmoregulation, and nitrogen fixation, amongst others []. The two-component system consists of a histidine protein kinase environmental sensor that phosphorylates the receiver domain of a response regulator protein; phosphorylation induces a conformational change in the response regulator, which activates the effector domain, triggering the cellular response []. The domains of the two-component proteins are highly modular, but the core structures and activities are maintained.The response regulators act as phosphorylation-activated switches to affect a cellular response, usually by transcriptional regulation. Most of these proteins consist of two domains, an N-terminal response regulator receiver domain, and a variable C-terminal effector domain with DNA-binding activity. This entry represents the response regulator receiver domain, which belongs to the CheY family, and receives the signal from the sensor partner in the two-component system. Short Name:  Sig_transdc_resp-reg_receiver
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF00072
PS50110
SM00448

20 Found Ins

DB identifier Type Name
IPR017053 Family Response regulator, plant B-type
IPR014525 Family Signal transduction histidine kinase, hybrid-type, ethylene sensor
IPR006291 Family Transcriptional regulatory protein PcoR, heavy metal response
IPR011879 Family Signal transduction response regulator, phosphate regulon transcriptional regulatory protein PhoB
IPR014402 Family Transcription factor, Skn7-like
IPR009219 Family Bacteriophytochrome, CheY-like
IPR014409 Family Signal transduction histidine kinase, hybrid-type, aerobic respiration control ArcB
IPR014302 Family Signal transduction histidine kinase, TMAO sensor TorS
IPR010114 Family Signal transduction response regulator, nitrogen regulation NR(I)
IPR014264 Family Signal transduction response regulator, PEP-CTERM system, putative
IPR016837 Family Uncharacterised protein family Ycf55, cyanobacteria
IPR014483 Family Fis-like DNA-binding domain-containing signal transduction response regulator, predicted
IPR014460 Family Signal transduction response regulator, predicted, VieB
IPR014605 Domain Signal transduction response regulator, PhyR-like, C-terminal, alphaproteobacteria
IPR014626 Family Signal transduction response regulator, modified HD-GYP domain-containing, putative
IPR012052 Family Sporulation transcription factor Spo0A
IPR017206 Family Signal transduction histidine kinase, hybrid-type, BC3207, predicted
IPR008248 Family Signal transduction response regulator, chemotaxis, CheB
IPR022305 Family Sortase system response regulator
IPR008327 Family Signal transduction response regulator, antiterminator

1 GO Annotation

GO Term Gene Name
GO:0000160 IPR001789

1 Ontology Annotations

GO Term Gene Name
GO:0000160 IPR001789

1 Parent Features

DB identifier Type Name
IPR011006 Domain CheY-like superfamily

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
162543 D8TAU9 PAC:15405347 Selaginella moellendorffii 440  
97396 D8RMZ7 PAC:15410084 Selaginella moellendorffii 78  
16699 D8SMD5 PAC:15418839 Selaginella moellendorffii 73  
267662 D8RRE6 PAC:15412834 Selaginella moellendorffii 736  
55684 PAC:15422229 Selaginella moellendorffii 251  
100467 D8RSK6 PAC:15422619 Selaginella moellendorffii 176  
101176 PAC:15423208 Selaginella moellendorffii 432  
7704 PAC:15404366 Selaginella moellendorffii 113  
415605 D8RWN5 PAC:15421622 Selaginella moellendorffii 190  
104037 D8RWN3 PAC:15408855 Selaginella moellendorffii 1086  
405045 PAC:15410073 Selaginella moellendorffii 1067  
438647 D8QX92 PAC:15422641 Selaginella moellendorffii 505  
107861 PAC:15401504 Selaginella moellendorffii 87  
152221 D8S3K5 PAC:15418237 Selaginella moellendorffii 905  
3025 PAC:15409785 Selaginella moellendorffii 328  
109384 PAC:15403497 Selaginella moellendorffii 465  
418583 D8S660 PAC:15407487 Selaginella moellendorffii 175  
55595 PAC:15421464 Selaginella moellendorffii 270  
110685 D8S7K1 PAC:15409088 Selaginella moellendorffii 747  
38684 PAC:15416709 Selaginella moellendorffii 113  
7960 D8S948 PAC:15406094 Selaginella moellendorffii 79  
444702 D8SC74 PAC:15418883 Selaginella moellendorffii 470  
115529 PAC:15422753 Selaginella moellendorffii 117  
84824 D8R4B8 PAC:15420072 Selaginella moellendorffii 740  
17396 PAC:15419438 Selaginella moellendorffii 134  
120989 D8SNB4 PAC:15418617 Selaginella moellendorffii 176  
20385 PAC:15406107 Selaginella moellendorffii 792  
163842 PAC:15410696 Selaginella moellendorffii 609  
36704 PAC:15411490 Selaginella moellendorffii 139  
231095 D8R9F4 PAC:15413947 Selaginella moellendorffii 965  

8 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12372152
            10966457
            16176121
            18076326
            11934609
            11489844
            7699720
            12015152