Protein Domain : IPR012052

Type:  Family Name:  Sporulation transcription factor Spo0A
Description:  Members of this group are response regulators/transcription factors that contain CheY-like receiver (phosphoacceptor) domain and a unique DNA-binding domain. Spo0A controls the entry of Bacillus subtilisinto the developmental process of sporulation []. Activation of the Spo0A transcription factor by phosphorylation serves as a developmental checkpoint and to integrate several physiological signals that control entry into the sporulation pathway. The signals are generated by conditions of nutrient deprivation, high cell density, the Krebs cycle, DNA replication, DNA damage, and some aspect of the chromosome partitioning machinery [].Activated Spo0A has multiple functions []. It represses promoters (such as the abrB promoter) by binding to sites (0A boxes) downstream from the transcription start site. Spo0A also activates transcription from promoters used by two forms of RNA polymerase that differ by containing either the major sigma factor, sigma A (e.g. the spoIIE and spoIIG promoters) or the alternate sigma factor, sigma H (e.g. the spoIIA promoter). At promoters activated by Spo0A, the 0A boxes lie upstream of the transcription-initiation site. Short Name:  Spore_0_A
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0 Child Features

2 Contains

DB identifier Type Name
IPR001789 Domain Signal transduction response regulator, receiver domain
IPR014879 Domain Sporulation initiation factor Spo0A, C-terminal

2 Cross Referencess

Identifier
PIRSF002937
TIGR02875

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR012052
GO:0005509 IPR012052
GO:0006355 IPR012052
GO:0043937 IPR012052
GO:0051606 IPR012052

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR012052
GO:0005509 IPR012052
GO:0006355 IPR012052
GO:0043937 IPR012052
GO:0051606 IPR012052

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11286862
            8464402