Protein Domain : IPR004709

Type:  Family Name:  Na+/H+ exchanger
Description:  Sodium proton exchangers (NHEs) constitute a large family of integral membrane protein transporters that are responsible for the counter-transport of protons and sodium ions across lipid bilayers [, ]. These proteins are found in organisms across all domains of life. In archaea, bacteria, yeast and plants, these exchangers provide increased salt tolerance by removing sodium in exchanger for extracellular protons. In mammals they participate in the regulation of cell pH, volume, and intracellular sodium concentration, as well as for the reabsorption of NaCl across renal, intestinal, and other epithelia [, , , ]. Human NHE is also involved in heart disease, cell growth and in cell differentiation []. The removal of intracellular protons in exchange for extracellular sodium effectively eliminates excess acid from actively metabolising cells. In mammalian cells, NHE activity is found in both the plasma membrane and inner mitochondrial membrane. To date, nine mammalian isoforms have been identified (designated NHE1-NHE9) [, ]. These exchangers are highly-regulated (glyco)phosphoproteins, which, based on their primary structure, appear to contain 10-12 membrane-spanning regions (M) at the N terminus and a large cytoplasmic region at the C terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family. There is some evidence that the exchangers may exist in the cell membrane as homodimers, but little is currently known about the mechanism of their antiport []. Short Name:  NaH_exchanger
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5 Child Features

DB identifier Type Name
IPR029872 Family Na+/H+ exchanger NHX -type, plants
IPR018409 Family Na+/H+ exchanger, isoform 8
IPR002090 Family Na+/H+ exchanger, isoform 6 (NHE6)
IPR001953 Family Na+/H+ exchanger, isoform 2 (NHE2)
IPR001970 Family Na+/H+ exchanger, isoform 1 (NHE1)

0 Contains

2 Cross Referencess

Identifier
PR01084
TIGR00840

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0015385 IPR004709
GO:0006814 IPR004709
GO:0006885 IPR004709
GO:0055085 IPR004709
GO:0016021 IPR004709

5 Ontology Annotations

GO Term Gene Name
GO:0015385 IPR004709
GO:0006814 IPR004709
GO:0006885 IPR004709
GO:0055085 IPR004709
GO:0016021 IPR004709

1 Parent Features

DB identifier Type Name
IPR018422 Family Cation/H+ exchanger, CPA1 family

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231555 D8RGI2 PAC:15417561 Selaginella moellendorffii 517  
97180 D8RMW6 PAC:15408431 Selaginella moellendorffii 314  
230648 D8R365 PAC:15415452 Selaginella moellendorffii 545  
163708 D8QQ21 PAC:15409799 Selaginella moellendorffii 487  
76526 D8QTM4 PAC:15416402 Selaginella moellendorffii 499  
evm.model.supercontig_16.109 PAC:16409951 Carica papaya 542  
evm.model.supercontig_31.41 PAC:16417186 Carica papaya 238  
evm.model.supercontig_48.7 PAC:16420931 Carica papaya 502  
evm.model.supercontig_9.167 PAC:16428054 Carica papaya 524  
29726.m003982 B9RSZ3 PAC:16806695 Ricinus communis 541  
30128.m008667 B9REW3 PAC:16818257 Ricinus communis 544  
30128.m008729 B9RF15 PAC:16818318 Ricinus communis 709  
27613.m000616 B9SSQ7 PAC:16798791 Ricinus communis 520  
29647.m002027 B9S3W7 PAC:16804672 Ricinus communis 536  
Cucsa.363260.1 A0A0A0KEJ3 PAC:16981063 Cucumis sativus 553  
Cucsa.025160.1 A0A0A0KAP3 PAC:16952012 Cucumis sativus 535  
Cucsa.025160.2 A0A0A0KAP3 PAC:16952013 Cucumis sativus 535  
Cucsa.180750.1 PAC:16967350 Cucumis sativus 437  
Cucsa.180760.2 PAC:16967351 Cucumis sativus 369  
Cucsa.281570.1 PAC:16974347 Cucumis sativus 223  
Cucsa.289150.1 A0A0A0LZ60 PAC:16975176 Cucumis sativus 532  
Cucsa.289150.11 PAC:16975178 Cucumis sativus 387  
Cucsa.289150.6 A0A0A0LZ60 PAC:16975183 Cucumis sativus 532  
orange1.1g037375m A0A067DEF4 PAC:18104485 Citrus sinensis 183  
orange1.1g047772m A0A067GG45 PAC:18112155 Citrus sinensis 498  
orange1.1g009116m A0A067G625 PAC:18105891 Citrus sinensis 543  
orange1.1g018715m A0A067GHW7 PAC:18105893 Citrus sinensis 351  
orange1.1g013653m A0A067G8V1 PAC:18105892 Citrus sinensis 439  
orange1.1g018758m A0A067GHW7 PAC:18105894 Citrus sinensis 351  
orange1.1g010004m A0A067F4C6 PAC:18099993 Citrus sinensis 520  

10 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9537504
            9278382
            9507001
            12027219
            12502567
            16734752
            17071327
            16513813
            11187762
            17218973