Protein Domain : IPR002353

Type:  Family Name:  Type-2 ice-structuring protein
Description:  Marine teleosts from polar oceans can be protected from freezing in icy sea-water by serum antifreeze proteins (AFPs) or glycoproteins (AFGPs) [].These function by binding to, and preventing the growth of, ice crystals within the fish. Despite functional similarity, the proteins arestructurally diverse and include glycosylated and at least 3 non-glycosylated forms: the AFGP of nototheniids and cod are polymers of a tripeptide repeat, Ala-Ala-Thr, with a disaccharide attached to thethreonine residue; type I AFPs are Ala-rich, alpha-helical peptides found in flounder and sculpin; type II AFPs of sea-raven, smelt andherring are Cys-rich proteins; and type III AFPs, found in Eel pouts, are rich in beta-structure. Although no direct structural information is available for type II AFPs,their sequences are similar to the carbohydrate recognition domain (CRD) of Ca2+-dependent lectins. This domain is present in a superfamily of proteins that bind sugars specifically through contact with a calciumion. The extent of similarity within the superfamily is confined to short motifs and single amino acids at intervals throughout the protein. Short Name:  AntifreezeII
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0 Child Features

2 Contains

DB identifier Type Name
IPR001304 Domain C-type lectin
IPR018378 Conserved_site C-type lectin, conserved site

1 Cross References

Identifier
PR00356

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Sphfalx0092s0073.3.p PAC:32610333 Sphagnum fallax 555  
Sphfalx0092s0073.2.p PAC:32610332 Sphagnum fallax 556  
AH008437-RA PAC:38172354 Amaranthus hypochondriacus 315  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7540906